Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin.
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The balance of myeloid populations and lymphoid populations must be well controlled. Here we found that osteopontin (OPN) skewed this balance during pathogenic conditions such as infection and autoimmunity. Notably, two isoforms of OPN exerted distinct effects in shifting this balance through cell-type-specific regulation of apoptosis. Intracellular OPN (iOPN) diminished the population size of myeloid progenitor cells and myeloid cells, and secreted OPN (sOPN) increase the population size of lymphoid cells. The total effect of OPN on skewing the leukocyte population balance was observed as host sensitivity to early systemic infection with Candida albicans and T cell-mediated colitis. Our study suggests previously unknown detrimental roles for two OPN isoforms in causing the imbalance of leukocyte populations.
Enzyme-Linked Immunosorbent Assay
Reverse Transcriptase Polymerase Chain Reaction
Real-Time Polymerase Chain Reaction
Published Version (Please cite this version)10.1038/ni.3791
Publication InfoShinohara, Mari; Gregory, Simon; Xu, Shengjie; Kanayama, Masashi; Danzaki, Keiko; Gibson, Jason R; & Inoue, Makoto (2017). Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. Nature immunology, 18(9). pp. 973-984. 10.1038/ni.3791. Retrieved from https://hdl.handle.net/10161/17648.
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Professor in Neurology
My principal area of research involves elucidating the molecular mechanisms underlying multi-factorial diseases. My lab is primarily interested identifying the complex genetic factors that give rise to multiple sclerosis, autism and cardiovascular disease. We are using targeted approaches to identify differential methylation of the oxytocin receptor gene (OXTR) in individuals with autism, and applying these data to an NICHD funded ACE award, SOARS-B, to assess long term use of oxytocin nasal spr
Associate Professor of Immunology
We need to mount a strong immune response against pathogens during infections, but excessive and uncontrolled immune reactions can lead to autoimmunity. How does our immune system keep the balance fine-tuned? This is a central question being asked in my laboratory.Immune system needs to detect pathogens quickly and effectively. This is performed by the innate immune system, which includes cells such as macrophages and dendritic cells (DCs). Pathogens are recog
Program Start Year: 2013Mari Shinohara Laboratory"Novel Heterogeneous Alveolar Macrophage Subpopulations during Early Fungal Infection"
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