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Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin.

dc.contributor.author Shinohara, Mari
dc.contributor.author Gregory, Simon
dc.contributor.author Xu, Shengjie
dc.contributor.author Kanayama, Masashi
dc.contributor.author Danzaki, Keiko
dc.contributor.author Gibson, Jason R
dc.contributor.author Inoue, Makoto
dc.date.accessioned 2018-11-11T21:11:03Z
dc.date.available 2018-11-11T21:11:03Z
dc.date.issued 2017-09
dc.identifier ni.3791
dc.identifier.issn 1529-2908
dc.identifier.issn 1529-2916
dc.identifier.uri https://hdl.handle.net/10161/17648
dc.description.abstract The balance of myeloid populations and lymphoid populations must be well controlled. Here we found that osteopontin (OPN) skewed this balance during pathogenic conditions such as infection and autoimmunity. Notably, two isoforms of OPN exerted distinct effects in shifting this balance through cell-type-specific regulation of apoptosis. Intracellular OPN (iOPN) diminished the population size of myeloid progenitor cells and myeloid cells, and secreted OPN (sOPN) increase the population size of lymphoid cells. The total effect of OPN on skewing the leukocyte population balance was observed as host sensitivity to early systemic infection with Candida albicans and T cell-mediated colitis. Our study suggests previously unknown detrimental roles for two OPN isoforms in causing the imbalance of leukocyte populations.
dc.language eng
dc.publisher NATURE PUBLISHING GROUP
dc.relation.ispartof Nature immunology
dc.relation.isversionof 10.1038/ni.3791
dc.subject Lymphocytes
dc.subject T-Lymphocytes
dc.subject Myeloid Cells
dc.subject Animals
dc.subject Mice, Knockout
dc.subject Mice
dc.subject Candida albicans
dc.subject Infection
dc.subject Candidiasis
dc.subject Colitis
dc.subject Autoimmune Diseases
dc.subject Protein Isoforms
dc.subject Enzyme-Linked Immunosorbent Assay
dc.subject Flow Cytometry
dc.subject Reverse Transcriptase Polymerase Chain Reaction
dc.subject Apoptosis
dc.subject Lymphopoiesis
dc.subject Myelopoiesis
dc.subject Cell Proliferation
dc.subject Osteopontin
dc.subject Real-Time Polymerase Chain Reaction
dc.title Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin.
dc.type Journal article
dc.date.updated 2018-11-11T21:10:57Z
pubs.begin-page 973
pubs.end-page 984
pubs.issue 9
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Duke Molecular Physiology Institute
pubs.organisational-group Molecular Genetics and Microbiology
pubs.organisational-group Basic Science Departments
pubs.organisational-group Neurology, MS & Neuroimmunology
pubs.organisational-group Neurology
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Immunology
pubs.organisational-group Student
pubs.publication-status Published
pubs.volume 18
duke.contributor.orcid Shinohara, Mari|0000-0002-6808-9844


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