Short-term effects of the DASH diet in adults with moderate chronic kidney disease: a pilot feeding study.
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Although the Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure (BP) for adults with normal kidney function, evidence is lacking regarding its safety and efficacy in chronic kidney disease (CKD). We aimed to test the effects of the DASH diet on serum electrolytes and BP in adults with moderate CKD.In a prospective before-after feeding study, 11 adults with an estimated glomerular filtration rate of 30-59 mL/min/1.73 m(2) and medication-treated hypertension were provided a reduced-sodium, run-in diet for 1 week followed by a reduced-sodium, DASH diet for 2 weeks. Changes in serum electrolytes and BP were compared pre-post DASH.Eleven participants underwent feeding; 1 completed 1 week and 10 completed 2 weeks of DASH. Compared with baseline, DASH modestly increased serum potassium at 1 week (mean ± standard deviation, +0.28 ± 0.4 mg/dL; P = 0.043) but had no significant effect on potassium at 2 weeks (+0.15 ± 0.28 mg/dL; P = 0.13). Serum bicarbonate was reduced (-2.5 ± 3.0 mg/dL; P = 0.03) at 2 weeks. Neither incident hyperkalemia nor new onset metabolic acidosis was observed. Clinic BP and mean 24-h ambulatory BP was unchanged. DASH significantly reduced mean nighttime BP (-5.3 ± 5.8 mmHg; P = 0.018), and enhanced percent declines in both nocturnal systolic BP (-2.1% to -5.1%; P = 0.004) and diastolic BP (-3.7% to -10.0%; P = 0.008).These pilot data suggest that a reduced-sodium DASH dietary pattern does not cause acute metabolic events in adults with moderate CKD and may improve nocturnal BP. Definitive studies are needed to determine long-term effects of DASH in CKD.
Published Version (Please cite this version)10.1093/ckj/sfw046
Publication InfoBatch, Bryan; Corsino, Leonor; Svetkey, Laura; Lin, Pao-Hwa; Barnhart, Huiman; Tyson, Crystal; ... Burroughs, Jasmine (2016). Short-term effects of the DASH diet in adults with moderate chronic kidney disease: a pilot feeding study. Clinical kidney journal, 9(4). pp. 592-598. 10.1093/ckj/sfw046. Retrieved from https://hdl.handle.net/10161/17678.
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Professor of Biostatistics and Bioinformatics
My research interests include both statistical methodology and disease-specific clinical research biostatistics. My statistical research areas include methods for assessing reliability/agreement between methods or raters, evaluating performance of new medical diagnostic tests, missing data, correlated categorical data and methods for clinical trials. My collaborative research include the following clinical areas: cardiovascular imaging, radiology imaging, cardiovascular disease, renal disea
Associate Professor of Medicine
Type 2 Diabetes, Obesity/Overweight, Behavior change, Non-pharmacologic intervention, Health disparities
Associate Professor of Medicine
Associate Professor in Medicine
My research interest lies generally in the area of dietary patterns and chronic diseases including hypertension using controlled feeding study and lifestyle intervention designs. Two major controlled feeding clinical trials that I was involved in include the Dietary Approaches to Stop Hypertension (DASH) Study and the Dietary Approaches to Stop Hypertension-Sodium (DASH-Sodium) Study. In addition to being an active member for the diet committee for DASH, I also function as the
Professor of Medicine
Laura P. Svetkey, MD MHS is Professor of Medicine, Director of the Duke Hypertension Center, Director of Clinical Research at the Sarah W. Stedman Nutrition and Metabolism Center, Vice Chair for Faculty Development and Diversity in the Department of Medicine. She is also the Director of Duke’s CTSA internal career development award program (KL2).She is a faculty member of the Duke Molecular Physiology Institute (DMPI) and the Cardiovascular Research Center (CVRC). She i
Assistant Professor of Medicine
As a board-certified nephrologist and a certified clinical hypertension specialist (ASH-SCH), I take care of patients with kidney disorders and/or high blood pressure. Patients with chronic kidney disease and high blood pressure have an increased risk for developing complications of cardiovascular disease, such as heart attacks, congestive heart failure, strokes, kidney failure requiring dialysis or a kidney transplant, and a shortened lifespan. My clinical focus is to slow the progression of
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