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Temporal resolution of single photon responses in primate rod photoreceptors and limits imposed by cellular noise.

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Date
2018-11-28
Authors
Field, Greg D
Uzzell, Valerie
Chichilnisky, EJ
Rieke, Fred
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Abstract
Sensory receptor noise corrupts sensory signals, contributing to imperfect perception and dictating central processing strategies. For example, noise in rod phototransduction limits our ability to detect light and minimizing the impact of this noise requires precisely tuned nonlinear processing by the retina. But detection sensitivity is only one aspect of night vision: prompt and accurate behavior also requires that rods reliably encode the timing of photon arrivals. We show here that the temporal resolution of responses of primate rods is much finer than the duration of the light response and identify the key limiting sources of transduction noise. We also find that the thermal activation rate of rhodopsin is lower than previous estimates, implying that other noise sources are more important than previously appreciated. A model of rod single-photon responses reveals that the limiting noise relevant for behavior depends critically on how rod signals are pooled by downstream neurons.
Type
Journal article
Subject
phototransduction
scotopic
signal processing
vision
Permalink
https://hdl.handle.net/10161/17856
Published Version (Please cite this version)
10.1152/jn.00683.2018
Publication Info
Field, Greg D; Uzzell, Valerie; Chichilnisky, EJ; & Rieke, Fred (2018). Temporal resolution of single photon responses in primate rod photoreceptors and limits imposed by cellular noise. Journal of neurophysiology. 10.1152/jn.00683.2018. Retrieved from https://hdl.handle.net/10161/17856.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Field

Greg D. Field

Adjunct Associate Professor of Neurobiology
My laboratory studies how the retina processes visual scenes and transmits this information to the brain.  We use multi-electrode arrays to record the activity of hundreds of retina neurons simultaneously in conjunction with transgenic mouse lines and chemogenetics to manipulate neural circuit function. We are interested in three major areas. First, we work to understand how neurons in the retina are functionally connected. Second we are studying how light-adaptation and circadian rhythms a
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