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Temporal resolution of single photon responses in primate rod photoreceptors and limits imposed by cellular noise.

dc.contributor.author Field, Greg
dc.contributor.author Uzzell, Valerie
dc.contributor.author Chichilnisky, EJ
dc.contributor.author Rieke, Fred
dc.date.accessioned 2019-01-03T15:06:49Z
dc.date.available 2019-01-03T15:06:49Z
dc.date.issued 2018-11-28
dc.identifier.issn 0022-3077
dc.identifier.issn 1522-1598
dc.identifier.uri https://hdl.handle.net/10161/17856
dc.description.abstract Sensory receptor noise corrupts sensory signals, contributing to imperfect perception and dictating central processing strategies. For example, noise in rod phototransduction limits our ability to detect light and minimizing the impact of this noise requires precisely tuned nonlinear processing by the retina. But detection sensitivity is only one aspect of night vision: prompt and accurate behavior also requires that rods reliably encode the timing of photon arrivals. We show here that the temporal resolution of responses of primate rods is much finer than the duration of the light response and identify the key limiting sources of transduction noise. We also find that the thermal activation rate of rhodopsin is lower than previous estimates, implying that other noise sources are more important than previously appreciated. A model of rod single-photon responses reveals that the limiting noise relevant for behavior depends critically on how rod signals are pooled by downstream neurons.
dc.language eng
dc.publisher American Physiological Society
dc.relation.ispartof Journal of neurophysiology
dc.relation.isversionof 10.1152/jn.00683.2018
dc.subject phototransduction
dc.subject scotopic
dc.subject signal processing
dc.subject vision
dc.title Temporal resolution of single photon responses in primate rod photoreceptors and limits imposed by cellular noise.
dc.type Journal article
dc.date.updated 2019-01-03T15:06:47Z
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Neurobiology
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group University Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.publication-status Published


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