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Optimal processing of photoreceptor signals is required to maximize behavioural sensitivity.

dc.contributor.author Field, Greg
dc.contributor.author Okawa, Haruhisa
dc.contributor.author Miyagishima, K Joshua
dc.contributor.author Arman, A Cyrus
dc.contributor.author Hurley, James B
dc.contributor.author Sampath, Alapakkam P
dc.date.accessioned 2019-01-03T15:34:22Z
dc.date.available 2019-01-03T15:34:22Z
dc.date.issued 2010-06
dc.identifier jphysiol.2010.188573
dc.identifier.issn 0022-3751
dc.identifier.issn 1469-7793
dc.identifier.uri https://hdl.handle.net/10161/17858
dc.description.abstract The sensitivity of receptor cells places a fundamental limit upon the sensitivity of sensory systems. For example, the signal-to-noise ratio of sensory receptors has been suggested to limit absolute thresholds in the visual and auditory systems. However, the necessity of optimally processing sensory receptor signals for behaviour to approach this limit has received less attention. We investigated the behavioural consequences of increasing the signal-to-noise ratio of the rod photoreceptor single-photon response in a transgenic mouse, the GCAPs-/- knockout. The loss of fast Ca2+ feedback to cGMP synthesis in phototransduction for GCAPs-/- mice increases the magnitude of the rod single-photon response and dark noise, with the increase in size of the single-photon response outweighing the increase in noise. Surprisingly, despite the increased rod signal-to-noise ratio, behavioural performance for GCAPs-/- mice was diminished near absolute visual threshold. We demonstrate in electrophysiological recordings that the diminished performance compared to wild-type mice is explained by poorly tuned postsynaptic processing of the rod single-photon response at the rod bipolar cell. In particular, the level of postsynaptic saturation in GCAPs-/- rod bipolar cells is not sufficient to eliminate rod noise, and degrades the single-photon response signal-to-noise ratio. Thus, it is critical for retinal processing to be optimally tuned near absolute threshold; otherwise the visual system fails to utilize fully the signals present in the rods.
dc.language eng
dc.publisher Wiley
dc.relation.ispartof The Journal of physiology
dc.relation.isversionof 10.1113/jphysiol.2010.188573
dc.subject Animals
dc.subject Mice, Knockout
dc.subject Mice
dc.subject Calibration
dc.subject Behavior, Animal
dc.subject Electrophysiology
dc.subject Excitatory Postsynaptic Potentials
dc.subject Light
dc.subject Retinal Bipolar Cells
dc.subject Guanylate Cyclase-Activating Proteins
dc.subject Retinal Rod Photoreceptor Cells
dc.title Optimal processing of photoreceptor signals is required to maximize behavioural sensitivity.
dc.type Journal article
dc.date.updated 2019-01-03T15:34:21Z
pubs.begin-page 1947
pubs.end-page 1960
pubs.issue Pt 11
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Neurobiology
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group University Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.publication-status Published
pubs.volume 588


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