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Functional connectivity in the retina at the resolution of photoreceptors.

dc.contributor.author Field, Greg
dc.contributor.author Gauthier, Jeffrey L
dc.contributor.author Sher, Alexander
dc.contributor.author Greschner, Martin
dc.contributor.author Machado, Timothy A
dc.contributor.author Jepson, Lauren H
dc.contributor.author Shlens, Jonathon
dc.contributor.author Gunning, Deborah E
dc.contributor.author Mathieson, Keith
dc.contributor.author Dabrowski, Wladyslaw
dc.contributor.author Paninski, Liam
dc.contributor.author Litke, Alan M
dc.contributor.author Chichilnisky, EJ
dc.date.accessioned 2019-01-03T15:36:22Z
dc.date.available 2019-01-03T15:36:22Z
dc.date.issued 2010-10
dc.identifier nature09424
dc.identifier.issn 0028-0836
dc.identifier.issn 1476-4687
dc.identifier.uri https://hdl.handle.net/10161/17861
dc.description.abstract To understand a neural circuit requires knowledge of its connectivity. Here we report measurements of functional connectivity between the input and ouput layers of the macaque retina at single-cell resolution and the implications of these for colour vision. Multi-electrode technology was used to record simultaneously from complete populations of the retinal ganglion cell types (midget, parasol and small bistratified) that transmit high-resolution visual signals to the brain. Fine-grained visual stimulation was used to identify the location, type and strength of the functional input of each cone photoreceptor to each ganglion cell. The populations of ON and OFF midget and parasol cells each sampled the complete population of long- and middle-wavelength-sensitive cones. However, only OFF midget cells frequently received strong input from short-wavelength-sensitive cones. ON and OFF midget cells showed a small non-random tendency to selectively sample from either long- or middle-wavelength-sensitive cones to a degree not explained by clumping in the cone mosaic. These measurements reveal computations in a neural circuit at the elementary resolution of individual neurons.
dc.language eng
dc.publisher Springer Nature
dc.relation.ispartof Nature
dc.relation.isversionof 10.1038/nature09424
dc.subject Neural Pathways
dc.subject Retinal Ganglion Cells
dc.subject Animals
dc.subject Macaca
dc.subject Macaca fascicularis
dc.subject Macaca mulatta
dc.subject Photic Stimulation
dc.subject Color Perception
dc.subject Light
dc.subject Color
dc.subject Models, Neurological
dc.subject Retinal Cone Photoreceptor Cells
dc.subject Color Vision
dc.title Functional connectivity in the retina at the resolution of photoreceptors.
dc.type Journal article
dc.date.updated 2019-01-03T15:36:21Z
pubs.begin-page 673
pubs.end-page 677
pubs.issue 7316
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Neurobiology
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group University Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.publication-status Published
pubs.volume 467


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