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A polyaxonal amacrine cell population in the primate retina.

dc.contributor.author Field, Greg
dc.contributor.author Greschner, Martin
dc.contributor.author Li, Peter H
dc.contributor.author Schiff, Max L
dc.contributor.author Gauthier, Jeffrey L
dc.contributor.author Ahn, Daniel
dc.contributor.author Sher, Alexander
dc.contributor.author Litke, Alan M
dc.contributor.author Chichilnisky, EJ
dc.date.accessioned 2019-01-03T15:39:12Z
dc.date.available 2019-01-03T15:39:12Z
dc.date.issued 2014-03
dc.identifier 34/10/3597
dc.identifier.issn 0270-6474
dc.identifier.issn 1529-2401
dc.identifier.uri https://hdl.handle.net/10161/17865
dc.description.abstract Amacrine cells are the most diverse and least understood cell class in the retina. Polyaxonal amacrine cells (PACs) are a unique subset identified by multiple long axonal processes. To explore their functional properties, populations of PACs were identified by their distinctive radially propagating spikes in large-scale high-density multielectrode recordings of isolated macaque retina. One group of PACs exhibited stereotyped functional properties and receptive field mosaic organization similar to that of parasol ganglion cells. These PACs had receptive fields coincident with their dendritic fields, but much larger axonal fields, and slow radial spike propagation. They also exhibited ON-OFF light responses, transient response kinetics, sparse and coordinated firing during image transitions, receptive fields with antagonistic surrounds and fine spatial structure, nonlinear spatial summation, and strong homotypic neighbor electrical coupling. These findings reveal the functional organization and collective visual signaling by a distinctive, high-density amacrine cell population.
dc.language eng
dc.publisher Society for Neuroscience
dc.relation.ispartof The Journal of neuroscience : the official journal of the Society for Neuroscience
dc.relation.isversionof 10.1523/JNEUROSCI.3359-13.2014
dc.subject Visual Pathways
dc.subject Amacrine Cells
dc.subject Axons
dc.subject Retinal Ganglion Cells
dc.subject Retina
dc.subject Animals
dc.subject Macaca fascicularis
dc.subject Macaca mulatta
dc.subject Photic Stimulation
dc.subject Female
dc.subject Male
dc.title A polyaxonal amacrine cell population in the primate retina.
dc.type Journal article
dc.date.updated 2019-01-03T15:39:10Z
pubs.begin-page 3597
pubs.end-page 3606
pubs.issue 10
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Neurobiology
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group University Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.publication-status Published
pubs.volume 34


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