Show simple item record

Effects of Initial Eye Position on Saccades Evoked by Microstimulation in the Primate Superior Colliculus: Implications for Models of the SC Read-Out Process.

dc.contributor.author Groh, Jennifer
dc.date.accessioned 2019-01-07T19:19:44Z
dc.date.available 2019-01-07T19:19:44Z
dc.date.issued 2011-01-19
dc.identifier.issn 1662-5145
dc.identifier.issn 1662-5145
dc.identifier.uri https://hdl.handle.net/10161/17897
dc.description.abstract The motor layers of the superior colliculus (SC) are thought to specify saccade amplitude and direction, independent of initial eye position. However, recent evidence suggests that eye position can modulate the level of activity of SC motor neurons. In this study, we tested whether initial eye position has an effect on microstimulation-evoked saccade amplitude. High (>300 Hz) and low (<300 Hz) frequency microstimulation was applied to 30 sites in the rostral part of the SC of two monkeys while they fixated one of six different locations. We found that the amplitude of the evoked saccades decreased with more contralateral initial eye positions. This effect was more pronounced in low frequency- compared to high frequency-evoked saccades, although it was present for both. Replication of these findings in head-free experiments showed that the effect of initial eye position was not due to physical constraints imposed by the oculomotor range. In addition to the effect of eye position on saccade amplitude, we also observed an increase in saccade latency and a decrease in the probability that microstimulation would evoke a saccade for low frequency stimulation at more contralateral eye positions. These findings suggest that an eye position signal can contribute to the read-out of the SC. Models of the saccadic pulse-step generator may need revision to incorporate an eye position modulation at the input stage.
dc.language eng
dc.publisher Frontiers Media SA
dc.relation.ispartof Frontiers in integrative neuroscience
dc.relation.isversionof 10.3389/fnint.2010.00130
dc.subject eye position
dc.subject monkey
dc.subject oculomotor
dc.subject pulse-step generator
dc.subject reference frame
dc.subject superior colliculus
dc.title Effects of Initial Eye Position on Saccades Evoked by Microstimulation in the Primate Superior Colliculus: Implications for Models of the SC Read-Out Process.
dc.type Journal article
dc.date.updated 2019-01-07T19:19:43Z
pubs.begin-page 130
pubs.issue JANUARFY 2011
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group Duke
pubs.organisational-group Psychology and Neuroscience
pubs.organisational-group Neurobiology
pubs.organisational-group Basic Science Departments
pubs.organisational-group School of Medicine
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group University Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Center for Cognitive Neuroscience
pubs.publication-status Published
pubs.volume 4
duke.contributor.orcid Groh, Jennifer|0000-0002-6435-3935


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record