Transcatheter Valve Replacement for Right-sided Valve Disease in Congenital Heart Patients.
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Pulmonary and/or tricuspid valve dysfunction is common among individuals with congenital heart disease, and surgical intervention often carries prohibitive risks. Transcatheter valve replacement (TVR) of the right-sided cardiac valves has become a viable treatment option over the past two decades, while continued technological development aims to broaden its applicability to an even larger portion of those with repaired congenital heart disease. To date, two transcatheter valves have been approved for use in patients with dysfunctional right ventricular to pulmonary artery conduits as well as those with failing pulmonic bioprosthetic valves, and are also used off-label in the "native" RVOT and within surgically repaired/replaced but failing tricuspid valves. TVR has demonstrated comparable safety and short-term outcomes to that of surgical valve replacement. This article aims to review current available devices, focusing on their safety, efficacy and on and off label usage, while briefly describing some of the emerging devices and novel procedural techniques that will likely lead to significant expansion of transcatheter treatment of right sided valve disease in the future.
Heart Defects, Congenital
Heart Valve Diseases
Heart Valve Prosthesis Implantation
Heart Valve Prosthesis
Published Version (Please cite this version)10.1016/j.pcad.2018.09.003
Publication InfoGales, Jordan; Krasuski, Richard A; & Fleming, Gregory A (2018). Transcatheter Valve Replacement for Right-sided Valve Disease in Congenital Heart Patients. Progress in cardiovascular diseases, 61(3-4). pp. 347-359. 10.1016/j.pcad.2018.09.003. Retrieved from https://hdl.handle.net/10161/17933.
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Gregory Allan Fleming
Professor of Pediatrics
Clinical interests include pediatric and adult congenital interventional cardiac catheterization and treatment of infants and children with acquired and congenital heart disease and adults with congenital heart disease Research interests include assessment and development of interventional therapies for congenital heart disease, and perioperative management of infants and children with congenital heart disease requiring surgery.
Richard Andrew Krasuski
Professor of Medicine
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