DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non-small-cell lung cancer.
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The DNA repair capacity (DRC) of tumor cells is an important contributor to resistance to radiation and platinum-based drugs. Because DRC may be affected by tumor cell metabolism, we measured DRC in lymphocytes from patients with non-small-cell lung cancer (NSCLC) and compared the findings with the maximum standardized uptake value (SUVmax) on18F-fluorodeoxyglucose positron emission tomography (FDG PET) after (chemo)radiation therapy.This study included 151 patients with stage IA-IV NSCLC who had FDG PET at a single institution and donated blood samples before chemotherapy. We assessed the correlation of DRC, measured in peripheral T lymphocytes by a host-cell reactivation assay with SUVmax and their associations with overall survival (OS) time by hazards ratios calculated with a Cox proportional hazards regression model.SUVmax of the primary tumor at diagnosis was inversely associated with lymphocyte DRC (r = -0.175, P = 0.032), particularly among patients with advanced disease (r = -0.218, P = 0.015). However, ΔSUVmax of primary tumor was not significantly associated with DRC (r = 0.005, P = 0.968). SUVmax of regional lymph nodes at diagnosis (r = -0.307, P = 0.0008) and after (chemo)radiation treatment (r = -0.329, P = 0.034) and SUVmax of the primary tumor after (chemo)radiation treatment (r = -0.253, P = 0.045) were also inversely associated with OS time.DRC was inversely associated with primary tumor SUVmax before treatment but not with ΔSUVmax after (chemo)radiation.
Subject18F-fluorodeoxyglucose positron emission tomography
DNA repair capacity
Non–small-cell lung cancer
Standardized uptake value
Published Version (Please cite this version)10.1016/j.cdtm.2018.05.003
Publication InfoWei, Qingyi; Jiang, Xin Eric; Xu, Ting; Li, Peng; Gomez, Daniel R; Court, Laurence E; & Liao, Zhongxing (2018). DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non-small-cell lung cancer. Chronic diseases and translational medicine, 4(2). pp. 109-116. 10.1016/j.cdtm.2018.05.003. Retrieved from https://hdl.handle.net/10161/17934.
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Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally recognized epidemiologist focused on the molecular and genetic epidemiology of head and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and genetic determinants for the DNA repair deficient phenotype and