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DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non-small-cell lung cancer.

dc.contributor.author Wei, Qingyi
dc.contributor.author Jiang, Xin Eric
dc.contributor.author Xu, Ting
dc.contributor.author Li, Peng
dc.contributor.author Gomez, Daniel R
dc.contributor.author Court, Laurence E
dc.contributor.author Liao, Zhongxing
dc.date.accessioned 2019-02-01T14:39:57Z
dc.date.available 2019-02-01T14:39:57Z
dc.date.issued 2018-06-13
dc.identifier S2095-882X(17)30093-2
dc.identifier.issn 2095-882X
dc.identifier.issn 2589-0514
dc.identifier.uri https://hdl.handle.net/10161/17934
dc.description.abstract The DNA repair capacity (DRC) of tumor cells is an important contributor to resistance to radiation and platinum-based drugs. Because DRC may be affected by tumor cell metabolism, we measured DRC in lymphocytes from patients with non-small-cell lung cancer (NSCLC) and compared the findings with the maximum standardized uptake value (SUVmax) on18F-fluorodeoxyglucose positron emission tomography (FDG PET) after (chemo)radiation therapy.This study included 151 patients with stage IA-IV NSCLC who had FDG PET at a single institution and donated blood samples before chemotherapy. We assessed the correlation of DRC, measured in peripheral T lymphocytes by a host-cell reactivation assay with SUVmax and their associations with overall survival (OS) time by hazards ratios calculated with a Cox proportional hazards regression model.SUVmax of the primary tumor at diagnosis was inversely associated with lymphocyte DRC (r = -0.175, P = 0.032), particularly among patients with advanced disease (r = -0.218, P = 0.015). However, ΔSUVmax of primary tumor was not significantly associated with DRC (r = 0.005, P = 0.968). SUVmax of regional lymph nodes at diagnosis (r = -0.307, P = 0.0008) and after (chemo)radiation treatment (r = -0.329, P = 0.034) and SUVmax of the primary tumor after (chemo)radiation treatment (r = -0.253, P = 0.045) were also inversely associated with OS time.DRC was inversely associated with primary tumor SUVmax before treatment but not with ΔSUVmax after (chemo)radiation.
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartof Chronic diseases and translational medicine
dc.relation.isversionof 10.1016/j.cdtm.2018.05.003
dc.subject 18F-fluorodeoxyglucose positron emission tomography
dc.subject DNA repair capacity
dc.subject Non–small-cell lung cancer
dc.subject Outcome
dc.subject Standardized uptake value
dc.title DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non-small-cell lung cancer.
dc.type Journal article
dc.date.updated 2019-02-01T14:39:56Z
pubs.begin-page 109
pubs.end-page 116
pubs.issue 2
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Population Health Sciences
pubs.organisational-group Basic Science Departments
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 4
duke.contributor.orcid Wei, Qingyi|0000-0002-3845-9445


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