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Associations of genotypes and haplotypes of IL-17 with risk of gastric cancer in an eastern Chinese population.

dc.contributor.author Wei, Qingyi
dc.contributor.author Zhou, Fei
dc.contributor.author Qiu, Li-Xin
dc.contributor.author Cheng, Lei
dc.contributor.author Wang, Meng-Yun
dc.contributor.author Li, Jin
dc.contributor.author Sun, Meng-Hong
dc.contributor.author Yang, Ya-Jun
dc.contributor.author Wang, Jiu-Cun
dc.contributor.author Jin, Li
dc.contributor.author Wang, Ya-Nong
dc.date.accessioned 2019-02-01T14:46:29Z
dc.date.available 2019-02-01T14:46:29Z
dc.date.issued 2016-12
dc.identifier 11616
dc.identifier.issn 1949-2553
dc.identifier.issn 1949-2553
dc.identifier.uri https://hdl.handle.net/10161/17947
dc.description.abstract Interleukin-17 plays a crucial role in inflammation-related carcinogenesis. We hypothesize that genetic variants in IL-17 are associated with gastric cancer (GCa) risk, and we genotyped five potentially functional single nucleotide polymorphisms (SNPs) (rs1974226 G > A, rs2275913 A > G, rs3819024 A > G, rs4711998 A > G, and rs8193036 C > T) of IL-17 in 1121 GCa patients and 1216 cancer-free controls in an eastern Chinese population. Logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI). Meta-analysis and genotype-mRNA expression correlation were performed to further validate positive associations. We found that an increased GCa risk was independently associated with rs1974226 (adjusted OR = 2.60, 95% CI = 1.27-5.32 for AA vs. GG + GA) and rs2275913 (adjusted OR = 1.33, 95% CI = 1.03-1.72 for GA + AA vs. GG), while a decreased GCa risk was independently associated with rs3819024 (adjusted OR = 0.72, 95% CI = 0.54-0.96 for GG vs. AA + AG). Additional meta-analyses confirmed the observed risk association with rs2275913. We also found that two IL-17 haplotypes (G-G-G-A-C) and (A-G-G-A-C) (in the order of rs1974226, rs2275913, rs3819024, rs4711998 and rs8193036) were associated with a reduced GCa risk (adjusted OR = 0.64, 95% CI = 0.46-0.89 and adjusted OR = 0.38, 95% CI = 0.17-0.81, respectively). However, the expression Quantitative Trait Locus (eQTL) analysis for the genotype-phenotype correlation did not find mRNA expression changes associated with either the genotypes. In conclusions, genetic variants of IL-17 are likely to be associated with risk of GCa, and additional larger studies with functional validation are needed to explore the molecular mechanisms underlying the observed associations.
dc.language eng
dc.publisher Impact Journals, LLC
dc.relation.ispartof Oncotarget
dc.relation.isversionof 10.18632/oncotarget.11616
dc.subject Cell Line, Tumor
dc.subject Humans
dc.subject Stomach Neoplasms
dc.subject Genetic Predisposition to Disease
dc.subject RNA, Messenger
dc.subject Interleukin-17
dc.subject Linear Models
dc.subject Logistic Models
dc.subject Odds Ratio
dc.subject Risk Assessment
dc.subject Risk Factors
dc.subject Chi-Square Distribution
dc.subject Case-Control Studies
dc.subject Gene Frequency
dc.subject Haplotypes
dc.subject Heterozygote
dc.subject Homozygote
dc.subject Phenotype
dc.subject Polymorphism, Single Nucleotide
dc.subject Quantitative Trait Loci
dc.subject Middle Aged
dc.subject Asian Continental Ancestry Group
dc.subject China
dc.subject Female
dc.subject Male
dc.subject Genetic Association Studies
dc.title Associations of genotypes and haplotypes of IL-17 with risk of gastric cancer in an eastern Chinese population.
dc.type Journal article
dc.date.updated 2019-02-01T14:46:27Z
pubs.begin-page 82384
pubs.end-page 82395
pubs.issue 50
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Population Health Sciences
pubs.organisational-group Basic Science Departments
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 7
duke.contributor.orcid Wei, Qingyi|0000-0002-3845-9445


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