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A Multifaceted Approach to Pulmonary Hypertension in Adults With Congenital Heart Disease.

dc.contributor.author Krasuski, Richard
dc.contributor.author Fathallah, Mouhammad
dc.date.accessioned 2019-02-01T14:47:09Z
dc.date.available 2019-02-01T14:47:09Z
dc.date.issued 2018-09
dc.identifier S0033-0620(18)30149-X
dc.identifier.issn 0033-0620
dc.identifier.issn 1873-1740
dc.identifier.uri https://hdl.handle.net/10161/17950
dc.description.abstract Advances in the management of congenital heart disease (CHD) in children have resulted in growing numbers of adults with CHD. Pulmonary arterial hypertension related to CHD (PAH-CHD) is a common complication, affecting up to 10% of patients; and can arise even after successful and complete defect repair, with severe and potentially fatal consequences. Careful work-up in these patients is essential, particularly hemodynamic assessment, and can help define the most appropriate therapeutic approach. Management can be challenging, but the therapeutic armamentarium is continually expanding and now includes surgical, transcatheter and medical options. Timely correction of defects along with early treatment with advanced medical therapies appears to improve quality of life and possible even improve survival. Interestingly most studies of PAH-CHD have focused on its most severely afflicted patients, those with Eisenmenger Syndrome, making it less certain how to manage PAH-CHD of milder degrees. This review summarizes our current understanding of PAH-CHD and emphasizes the need for close follow-up in specialized centers of care where close collaboration is common practice.
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartof Progress in cardiovascular diseases
dc.relation.isversionof 10.1016/j.pcad.2018.07.017
dc.subject Humans
dc.subject Hypertension, Pulmonary
dc.subject Heart Defects, Congenital
dc.subject Eisenmenger Complex
dc.subject Adult
dc.subject Patient Care Management
dc.subject Hemodynamics
dc.subject Early Medical Intervention
dc.title A Multifaceted Approach to Pulmonary Hypertension in Adults With Congenital Heart Disease.
dc.type Journal article
dc.date.updated 2019-02-01T14:47:08Z
pubs.begin-page 320
pubs.end-page 327
pubs.issue 3-4
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 61
duke.contributor.orcid Krasuski, Richard|0000-0003-3150-5215


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