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Plasma antibodies against heat shock protein 70 correlate with the incidence and severity of asthma in a Chinese population.

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Date
2005-01
Authors
Yang, Miao
Wu, Tangchun
Cheng, Longxian
Wang, Feng
Wei, Qingyi
Tanguay, Robert M
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Abstract
BACKGROUND: The heat shock proteins (Hsps) are induced by stresses such as allergic factors and inflammatory responses in bronchi epithelial cells and therefore may be detectable in patients with asthma. However, the etiologic link between anti-Hsps and asthma (its severity and related inflammatory responses such as interleukin-4 and immunoglobulin E) has not been established. We determined whether antibodies against Hsp60 and Hsp70 were present in patients with asthma and evaluated their associations with risk and severity of asthma. METHODS: We determined the levels of anti-Hsp60 and anti-Hsp70 by immunoblot and their associations with risk and symptom severity of asthma in 95 patients with asthma and 99 matched non-symptomatic controls using multivariate logistic regression analysis. RESULTS: Compared to the controls, asthma patients were more likely to have detectable anti-Hsp60 (17.2% vs 5.1%) and anti-Hsp70 (33.7% vs 8.1%) (p < or = 0.001). In particular, the presence of anti-Hsp70 was associated with a greater than 2 fold risk for asthma (adjusted OR = 2.21; 95% CI = 1.35 approximately 3.59). Furthermore, both anti-Hsp60 and anti-Hsp70 levels were positively correlated with symptom severity (p < 0.05) as well as interleukin-4 and immunoglobulin E (p < 0.05). Individuals with antibodies against anti-Hsp60 and anti-Hsp70 were more likely to have a family history of asthma (p < 0.001) and higher plasma concentrations of total immunoglobulin E (p = 0.001) and interleukin-4 (p < 0.05) than those without antibodies. CONCLUSIONS: These data suggest that anti-Hsp60 and especially anti-Hsp70 correlate with the attacks and severity of asthma. The underlying molecular mechanisms linking antibodies to heat shock proteins and asthma remain to be investigated.
Type
Journal article
Subject
Humans
Asthma
Autoantibodies
Severity of Illness Index
Incidence
Risk Assessment
Risk Factors
Adolescent
Adult
Middle Aged
Child
China
Female
Male
HSP70 Heat-Shock Proteins
Permalink
https://hdl.handle.net/10161/17964
Published Version (Please cite this version)
10.1186/1465-9921-6-18
Publication Info
Yang, Miao; Wu, Tangchun; Cheng, Longxian; Wang, Feng; Wei, Qingyi; & Tanguay, Robert M (2005). Plasma antibodies against heat shock protein 70 correlate with the incidence and severity of asthma in a Chinese population. Respiratory research, 6(1). pp. 18. 10.1186/1465-9921-6-18. Retrieved from https://hdl.handle.net/10161/17964.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Wei

Qingyi Wei

Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally recognized epidemiologist focused on the molecular and genetic epidemiology of head and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and genetic determinants for the DNA repair deficient phenotype and
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