Show simple item record

Plasma antibodies against heat shock protein 70 correlate with the incidence and severity of asthma in a Chinese population.

dc.contributor.author Yang, Miao
dc.contributor.author Wu, Tangchun
dc.contributor.author Cheng, Longxian
dc.contributor.author Wang, Feng
dc.contributor.author Wei, Qingyi
dc.contributor.author Tanguay, Robert M
dc.date.accessioned 2019-02-01T15:03:11Z
dc.date.available 2019-02-01T15:03:11Z
dc.date.issued 2005-01
dc.identifier 1465-9921-6-18
dc.identifier.issn 1465-9921
dc.identifier.issn 1465-993X
dc.identifier.uri https://hdl.handle.net/10161/17964
dc.description.abstract BACKGROUND: The heat shock proteins (Hsps) are induced by stresses such as allergic factors and inflammatory responses in bronchi epithelial cells and therefore may be detectable in patients with asthma. However, the etiologic link between anti-Hsps and asthma (its severity and related inflammatory responses such as interleukin-4 and immunoglobulin E) has not been established. We determined whether antibodies against Hsp60 and Hsp70 were present in patients with asthma and evaluated their associations with risk and severity of asthma. METHODS: We determined the levels of anti-Hsp60 and anti-Hsp70 by immunoblot and their associations with risk and symptom severity of asthma in 95 patients with asthma and 99 matched non-symptomatic controls using multivariate logistic regression analysis. RESULTS: Compared to the controls, asthma patients were more likely to have detectable anti-Hsp60 (17.2% vs 5.1%) and anti-Hsp70 (33.7% vs 8.1%) (p < or = 0.001). In particular, the presence of anti-Hsp70 was associated with a greater than 2 fold risk for asthma (adjusted OR = 2.21; 95% CI = 1.35 approximately 3.59). Furthermore, both anti-Hsp60 and anti-Hsp70 levels were positively correlated with symptom severity (p < 0.05) as well as interleukin-4 and immunoglobulin E (p < 0.05). Individuals with antibodies against anti-Hsp60 and anti-Hsp70 were more likely to have a family history of asthma (p < 0.001) and higher plasma concentrations of total immunoglobulin E (p = 0.001) and interleukin-4 (p < 0.05) than those without antibodies. CONCLUSIONS: These data suggest that anti-Hsp60 and especially anti-Hsp70 correlate with the attacks and severity of asthma. The underlying molecular mechanisms linking antibodies to heat shock proteins and asthma remain to be investigated.
dc.language eng
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartof Respiratory research
dc.relation.isversionof 10.1186/1465-9921-6-18
dc.subject Humans
dc.subject Asthma
dc.subject Autoantibodies
dc.subject Severity of Illness Index
dc.subject Incidence
dc.subject Risk Assessment
dc.subject Risk Factors
dc.subject Adolescent
dc.subject Adult
dc.subject Middle Aged
dc.subject Child
dc.subject China
dc.subject Female
dc.subject Male
dc.subject HSP70 Heat-Shock Proteins
dc.title Plasma antibodies against heat shock protein 70 correlate with the incidence and severity of asthma in a Chinese population.
dc.type Journal article
duke.contributor.id Wei, Qingyi|0632334
dc.date.updated 2019-02-01T15:03:10Z
pubs.begin-page 18
pubs.issue 1
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Population Health Sciences
pubs.organisational-group Basic Science Departments
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 6
duke.contributor.orcid Wei, Qingyi|0000-0002-3845-9445


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record