Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study.
Abstract
BACKGROUND: The nucleotide excision repair (NER) protein, xeroderma pigmentosum C
(XPC), participates in recognizing DNA lesions and initiating DNA repair in response
to DNA damage. Because mutations in XPC cause a high risk of cancer in XP patients,
we hypothesized that inherited sequence variations in XPC may alter DNA repair and
thus susceptibility to cancer. METHODS: In this hospital-based case-control study,
we investigated five XPC tagging, common single nucleotide polymorphisms (tagging
SNPs) in 1,010 patients with newly diagnosed lung cancer and 1,011 matched cancer
free controls in a Chinese population. RESULTS: In individual tagging SNP analysis,
we found that rs3731055AG+AA variant genotypes were associated with a significantly
decreased risk of lung adenocarcinoma [adjusted odds ratio (OR), 0.71; 95% confidence
interval (CI), 0.56-0.90] but an increased risk of small cell carcinomas [adjusted
OR, 1.79; 95% CI, 1.05-3.07]. Furthermore, we found that haplotype ACCCA was associated
with a decreased risk of lung adenocarcinoma [OR, 0.78; 95% CI, 0.62-0.97] but an
increased risk of small cell carcinomas [OR, 1.68; 95% CI, 1.04-2.71], which reflected
the presence of rs3731055A allele in this haplotype. Further stratified analysis revealed
that the protective effect of rs3731055AG+AA on risk of lung adenocarcinoma was more
evident among young subjects (age < or= 60) and never smokers. CONCLUSION: These results
suggest that inherited sequence variations in XPC may modulate risk of lung cancer,
especially lung adenocarcinoma, in Chinese populations. However, these findings need
to be verified in larger confirmatory studies with more comprehensively selected tagging
SNPs.
Type
Journal articleSubject
HumansLung Neoplasms
Endonucleases
DNA-Binding Proteins
Nuclear Proteins
Transcription Factors
Risk Factors
Case-Control Studies
DNA Repair
Aged
Middle Aged
Asian Continental Ancestry Group
Genetic Variation
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https://hdl.handle.net/10161/17969Published Version (Please cite this version)
10.1186/1471-2407-7-81Publication Info
Bai, Yun; Xu, Liang; Yang, Xiaobo; Hu, Zhibin; Yuan, Jing; Wang, Feng; ... Wu, Tangchun (2007). Sequence variations in DNA repair gene XPC is associated with lung cancer risk in
a Chinese population: a case-control study. BMC cancer, 7(1). pp. 81. 10.1186/1471-2407-7-81. Retrieved from https://hdl.handle.net/10161/17969.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Qingyi Wei
Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director
for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology
and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally
recognized epidemiologist focused on the molecular and genetic epidemiology of head
and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and
genetic determinants for the DNA repair deficient phenotype and

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