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Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study.

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Date
2007-01
Authors
Bai, Yun
Xu, Liang
Yang, Xiaobo
Hu, Zhibin
Yuan, Jing
Wang, Feng
Shao, Minhua
Yuan, Wentao
Qian, Ji
Ma, Hongxia
Wang, Ying
Liu, Hongliang
Chen, Weihong
Yang, Lin
Jing, Guangfu
Huo, Xiang
Chen, Feng
Liu, Yanhong
Jin, Li
Wei, Qingyi
Huang, Wei
Shen, Hongbing
Lu, Daru
Wu, Tangchun
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Abstract
BACKGROUND: The nucleotide excision repair (NER) protein, xeroderma pigmentosum C (XPC), participates in recognizing DNA lesions and initiating DNA repair in response to DNA damage. Because mutations in XPC cause a high risk of cancer in XP patients, we hypothesized that inherited sequence variations in XPC may alter DNA repair and thus susceptibility to cancer. METHODS: In this hospital-based case-control study, we investigated five XPC tagging, common single nucleotide polymorphisms (tagging SNPs) in 1,010 patients with newly diagnosed lung cancer and 1,011 matched cancer free controls in a Chinese population. RESULTS: In individual tagging SNP analysis, we found that rs3731055AG+AA variant genotypes were associated with a significantly decreased risk of lung adenocarcinoma [adjusted odds ratio (OR), 0.71; 95% confidence interval (CI), 0.56-0.90] but an increased risk of small cell carcinomas [adjusted OR, 1.79; 95% CI, 1.05-3.07]. Furthermore, we found that haplotype ACCCA was associated with a decreased risk of lung adenocarcinoma [OR, 0.78; 95% CI, 0.62-0.97] but an increased risk of small cell carcinomas [OR, 1.68; 95% CI, 1.04-2.71], which reflected the presence of rs3731055A allele in this haplotype. Further stratified analysis revealed that the protective effect of rs3731055AG+AA on risk of lung adenocarcinoma was more evident among young subjects (age < or= 60) and never smokers. CONCLUSION: These results suggest that inherited sequence variations in XPC may modulate risk of lung cancer, especially lung adenocarcinoma, in Chinese populations. However, these findings need to be verified in larger confirmatory studies with more comprehensively selected tagging SNPs.
Type
Journal article
Subject
Humans
Lung Neoplasms
Endonucleases
DNA-Binding Proteins
Nuclear Proteins
Transcription Factors
Risk Factors
Case-Control Studies
DNA Repair
Aged
Middle Aged
Asian Continental Ancestry Group
Genetic Variation
Permalink
https://hdl.handle.net/10161/17969
Published Version (Please cite this version)
10.1186/1471-2407-7-81
Publication Info
Bai, Yun; Xu, Liang; Yang, Xiaobo; Hu, Zhibin; Yuan, Jing; Wang, Feng; ... Wu, Tangchun (2007). Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study. BMC cancer, 7(1). pp. 81. 10.1186/1471-2407-7-81. Retrieved from https://hdl.handle.net/10161/17969.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Wei

Qingyi Wei

Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally recognized epidemiologist focused on the molecular and genetic epidemiology of head and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and genetic determinants for the DNA repair deficient phenotype and
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