The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.
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Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression of many cancers. In this study, we investigated the association between potentially functional SNPs of these two genes and risk of gastric cancer in a US population.The risk associated with genotypes and haplotypes of four TGFB1 SNPs and four VEGF SNPs were determined by multivariate logistic regression analysis in 171 patients with gastric cancer and 353 cancer-free controls frequency-matched by age, sex and ethnicity.Compared with the VEGF-634GG genotype, the -634CG genotype and the combined -634CG+CC genotypes were associated with a significantly elevated risk of gastric cancer (adjusted OR = 1.88, 95% CI = 1.24-2.86 and adjusted OR = 1.56, 95% CI = 1.07-2.27, respectively). However, none of other TGFB1 and VEGF SNPs was associated with risk of gastric cancer.Our data suggested that the VEGF-634G>C SNP may be a marker for susceptibility to gastric cancer, and this finding needs to be validated in larger studies.
Genetic Predisposition to Disease
Vascular Endothelial Growth Factor A
Polymorphism, Single Nucleotide
Aged, 80 and over
Transforming Growth Factor beta1
Promoter Regions, Genetic
Published Version (Please cite this version)10.1186/1471-230x-9-77
Publication InfoGuan, Xiaoxiang; Zhao, Hui; Niu, Jiangong; Tang, Dongfeng; Ajani, Jaffer A; & Wei, Qingyi (2009). The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer. BMC gastroenterology, 9(1). pp. 77. 10.1186/1471-230x-9-77. Retrieved from https://hdl.handle.net/10161/17971.
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Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally recognized epidemiologist focused on the molecular and genetic epidemiology of head and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and genetic determinants for the DNA repair deficient phenotype and