Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study.
Abstract
BACKGROUND: Non-Hodgkin's lymphoma (NHL) has been reported to be associated with autoimmune
and pro-inflammatory response, and genetic polymorphisms of candidate genes involved
in autoimmune and pro-inflammatory response may influence the susceptibility to NHL.
To evaluate the role of such genetic variations in risk of NHL, we conducted a case-control
study of 514 NHL patients and 557 cancer-free controls in a Chinese population. METHOD:
We used the Taqman assay to genotype six potentially functional single nucleotide
polymorphisms (SNPs) in six previously reported inflammation and immune-related genes
(TNF rs1799964T>C, LTA rs1800683G>A, IL-10 rs1800872T>G, LEP rs2167270G>A, LEPR rs1327118C>G,
TNFAIP8 rs1045241C>T). Logistic regression models were used to estimate odds ratios
(ORs) and 95% confidence intervals (95% CI). RESULTS: We observed a significantly
increased risk of NHL associated with the TNFAIP8 rs1045241C>T polymorphism (adjusted
OR = 3.03; 95% CI = 1.68-5.45 for TT vs. CC and adjusted OR = 2.03; 95% CI = 1.53-2.69
for CT/TT vs. CC). The risk associated with the T allele was more evident in subgroups
of 40-60 year-old, non-smokers or light-smokers (less than 25 pack-years), and subjects
with normal weight or overweight. Risk for both B and T cell non-Hodgkin's lymphoma
was elevated for CT/TT genotypes (adjusted OR = 1.95, 95% CI = 1.41-2.70 for B cell
NHL and adjusted OR = 2.22, 95% CI = 1.49-3.30 for T cell NHL), particularly for DLBCL
(adjusted OR = 2.01, 95%CI = 1.41-2.85) and FL (adjusted OR = 2.53, 95% CI = 1.17-5.45).
These risks were not observed for variant genotypes of other five SNPs compared with
their common homozygous genotypes. CONCLUSIONS: The polymorphism of TNFAIP8 rs1045241C>T
may contribute to NHL susceptibility in a Chinese population. Further large-scale
and well-designed studies are needed to confirm these results.
Type
Journal articleSubject
HumansLymphoma, Non-Hodgkin
Genetic Predisposition to Disease
Case-Control Studies
Polymorphism, Single Nucleotide
Adolescent
Adult
Aged
Aged, 80 and over
Middle Aged
Asian Continental Ancestry Group
Female
Male
Apoptosis Regulatory Proteins
Young Adult
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https://hdl.handle.net/10161/17979Published Version (Please cite this version)
10.1371/journal.pone.0037846Publication Info
Zhang, Yan; Wang, Meng-Yun; He, Jing; Wang, Jiu-Cun; Yang, Ya-Jun; Jin, Li; ... Zhou,
Xiao-Yan (2012). Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma
in a Chinese population: a case-control study. PloS one, 7(5). pp. e37846. 10.1371/journal.pone.0037846. Retrieved from https://hdl.handle.net/10161/17979.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Qingyi Wei
Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director
for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology
and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally
recognized epidemiologist focused on the molecular and genetic epidemiology of head
and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and
genetic determinants for the DNA repair deficient phenotype and

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