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Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer.

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Date
2012-01
Authors
Wang, Zhongqiu
Sturgis, Erich M
Guo, Wei
Song, Xicheng
Zhang, Fenghua
Xu, Li
Wei, Qingyi
Li, Guojun
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Abstract
p53 and p73 interact with human papillomavirus (HPV) E6 and E7 oncoproteins. The interplay between p53 and p73 and HPV16 may lead to deregulation of cell cycle and apoptosis, through which inflammation/immune responses control the HPV clearance and escape of immune surveillance, and subsequently contribute to tumor HPV16 status. In this case-case comparison study, HPV16 status in tumor specimens was analyzed and p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms were genotyped using genomic DNA from blood of 309 oropharyngeal cancer patients. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated in univariate and multivariable logistic regression models to examine the association. The results from this study showed both p53 variant genotypes (Arg/Pro+Pro/Pro) and p73 variant genotypes (GC/AT+AT/AT) were significantly associated with HPV16-positive tumor in oropharyngeal cancer patients (OR, 1.9, 95% CI, 1.1-3.3 and OR, 2.1, 95% CI, 1.2-3.8, respectively), while the combined variant genotypes (p53 Pro carriers and p73 AT carriers) exhibited a significantly greater association with HPV16-positive tumor (OR, 3.2, 95% CI, 1.4-7.4), compared with combined wild-type genotypes (p53 Arg/Arg and p73 GC/GC), and the association was in a statistically significant dose-effect relationship (p = 0.001). Moreover, such association was more pronounced among several subgroups. These findings suggest that variant genotypes of p53 and p73 genes may be individually, or more likely jointly, associated with tumor HPV16-positive oropharyngeal cancer patients, particularly in never smokers. Identification of such susceptible biomarkers would greatly influence on individualized treatment for an improved prognosis.
Type
Journal article
Subject
Humans
Oropharyngeal Neoplasms
DNA-Binding Proteins
Tumor Suppressor Proteins
Nuclear Proteins
Logistic Models
Polymorphism, Genetic
Genes, p53
Adult
Aged
Aged, 80 and over
Middle Aged
Female
Male
Tumor Suppressor Protein p53
Human papillomavirus 16
Biomarkers, Tumor
Tumor Protein p73
Permalink
https://hdl.handle.net/10161/17980
Published Version (Please cite this version)
10.1371/journal.pone.0035522
Publication Info
Wang, Zhongqiu; Sturgis, Erich M; Guo, Wei; Song, Xicheng; Zhang, Fenghua; Xu, Li; ... Li, Guojun (2012). Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer. PloS one, 7(4). pp. e35522. 10.1371/journal.pone.0035522. Retrieved from https://hdl.handle.net/10161/17980.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Wei

Qingyi Wei

Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally recognized epidemiologist focused on the molecular and genetic epidemiology of head and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and genetic determinants for the DNA repair deficient phenotype and
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