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Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer.

dc.contributor.author Wang, Zhongqiu
dc.contributor.author Sturgis, Erich M
dc.contributor.author Guo, Wei
dc.contributor.author Song, Xicheng
dc.contributor.author Zhang, Fenghua
dc.contributor.author Xu, Li
dc.contributor.author Wei, Qingyi
dc.contributor.author Li, Guojun
dc.date.accessioned 2019-02-01T15:10:47Z
dc.date.available 2019-02-01T15:10:47Z
dc.date.issued 2012-01
dc.identifier PONE-D-12-01678
dc.identifier.issn 1932-6203
dc.identifier.issn 1932-6203
dc.identifier.uri https://hdl.handle.net/10161/17980
dc.description.abstract p53 and p73 interact with human papillomavirus (HPV) E6 and E7 oncoproteins. The interplay between p53 and p73 and HPV16 may lead to deregulation of cell cycle and apoptosis, through which inflammation/immune responses control the HPV clearance and escape of immune surveillance, and subsequently contribute to tumor HPV16 status. In this case-case comparison study, HPV16 status in tumor specimens was analyzed and p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms were genotyped using genomic DNA from blood of 309 oropharyngeal cancer patients. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated in univariate and multivariable logistic regression models to examine the association. The results from this study showed both p53 variant genotypes (Arg/Pro+Pro/Pro) and p73 variant genotypes (GC/AT+AT/AT) were significantly associated with HPV16-positive tumor in oropharyngeal cancer patients (OR, 1.9, 95% CI, 1.1-3.3 and OR, 2.1, 95% CI, 1.2-3.8, respectively), while the combined variant genotypes (p53 Pro carriers and p73 AT carriers) exhibited a significantly greater association with HPV16-positive tumor (OR, 3.2, 95% CI, 1.4-7.4), compared with combined wild-type genotypes (p53 Arg/Arg and p73 GC/GC), and the association was in a statistically significant dose-effect relationship (p = 0.001). Moreover, such association was more pronounced among several subgroups. These findings suggest that variant genotypes of p53 and p73 genes may be individually, or more likely jointly, associated with tumor HPV16-positive oropharyngeal cancer patients, particularly in never smokers. Identification of such susceptible biomarkers would greatly influence on individualized treatment for an improved prognosis.
dc.language eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PloS one
dc.relation.isversionof 10.1371/journal.pone.0035522
dc.subject Humans
dc.subject Oropharyngeal Neoplasms
dc.subject DNA-Binding Proteins
dc.subject Tumor Suppressor Proteins
dc.subject Nuclear Proteins
dc.subject Logistic Models
dc.subject Polymorphism, Genetic
dc.subject Genes, p53
dc.subject Adult
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Middle Aged
dc.subject Female
dc.subject Male
dc.subject Tumor Suppressor Protein p53
dc.subject Human papillomavirus 16
dc.subject Biomarkers, Tumor
dc.subject Tumor Protein p73
dc.title Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer.
dc.type Journal article
duke.contributor.id Wei, Qingyi|0632334
dc.date.updated 2019-02-01T15:10:47Z
pubs.begin-page e35522
pubs.issue 4
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Population Health Sciences
pubs.organisational-group Basic Science Departments
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 7
duke.contributor.orcid Wei, Qingyi|0000-0002-3845-9445


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