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Association between XPF polymorphisms and cancer risk: a meta-analysis.

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Date
2012-01
Authors
Shi, Ting-Yan
He, Jing
Qiu, Li-Xin
Zhu, Mei-Ling
Wang, Meng-Yun
Zhou, Xiao-Yan
Han, Jiali
Yu, Hongpin
Zang, Rong-Yu
Wei, Qingyi
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Abstract
BACKGROUND: Xeroderma pigmentosum complementation group F (XPF or ERCC4) plays a key role in DNA repair that protects against genetic instability and carcinogenesis. A series of epidemiological studies have examined associations between XPF polymorphisms and cancer risk, but the findings remain inconclusive. METHODOLOGY/PRINCIPAL FINDINGS: In this meta-analysis of 47,639 cancer cases and 51,915 controls, by searching three electronic databases (i.e., MEDLINE, EMBASE and CNKI), we summarized 43 case-control studies from 29 publications on four commonly studied polymorphisms of XPF (i.e., rs1800067, rs1799801, rs2020955 and rs744154), and we did not find statistical evidence of any significant association with overall cancer risk. However, in stratification analyses, we found a significant association of XPF-rs1799801 with a reduced cancer risk in Caucasian populations (4,845 cases and 5,556 controls; recessive model: OR=0.87, 95% CI=0.76-1.00, P=0.049, P=0.723 for heterogeneity test, I(2) =0). Further genotype-phenotype correlation analysis showed that the homozygous variant CC genotype carriers had higher XPF expression levels than that of the TT genotype carriers (Student's t test for a recessive model: P=0.046). No publication bias was found by using the funnel plot and Egger's test. CONCLUSION: This meta-analysis suggests a lack of statistical evidence for the association between the four XPF SNPs and overall risk of cancers. However, XPF-rs1799801 may be associated with cancer risk in Caucasian populations, which needs to be further validated in single large, well-designed prospective studies.
Type
Journal article
Subject
Humans
Neoplasms
DNA-Binding Proteins
Neoplasm Proteins
Risk Factors
Case-Control Studies
Gene Expression Regulation, Neoplastic
Genotype
Polymorphism, Single Nucleotide
European Continental Ancestry Group
Female
Male
Permalink
https://hdl.handle.net/10161/17981
Published Version (Please cite this version)
10.1371/journal.pone.0038606
Publication Info
Shi, Ting-Yan; He, Jing; Qiu, Li-Xin; Zhu, Mei-Ling; Wang, Meng-Yun; Zhou, Xiao-Yan; ... Wei, Qingyi (2012). Association between XPF polymorphisms and cancer risk: a meta-analysis. PloS one, 7(7). pp. e38606. 10.1371/journal.pone.0038606. Retrieved from https://hdl.handle.net/10161/17981.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Wei

Qingyi Wei

Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally recognized epidemiologist focused on the molecular and genetic epidemiology of head and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and genetic determinants for the DNA repair deficient phenotype and
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