Association between XPF polymorphisms and cancer risk: a meta-analysis.
Abstract
BACKGROUND: Xeroderma pigmentosum complementation group F (XPF or ERCC4) plays a key
role in DNA repair that protects against genetic instability and carcinogenesis. A
series of epidemiological studies have examined associations between XPF polymorphisms
and cancer risk, but the findings remain inconclusive. METHODOLOGY/PRINCIPAL FINDINGS:
In this meta-analysis of 47,639 cancer cases and 51,915 controls, by searching three
electronic databases (i.e., MEDLINE, EMBASE and CNKI), we summarized 43 case-control
studies from 29 publications on four commonly studied polymorphisms of XPF (i.e.,
rs1800067, rs1799801, rs2020955 and rs744154), and we did not find statistical evidence
of any significant association with overall cancer risk. However, in stratification
analyses, we found a significant association of XPF-rs1799801 with a reduced cancer
risk in Caucasian populations (4,845 cases and 5,556 controls; recessive model: OR=0.87,
95% CI=0.76-1.00, P=0.049, P=0.723 for heterogeneity test, I(2) =0). Further genotype-phenotype
correlation analysis showed that the homozygous variant CC genotype carriers had higher
XPF expression levels than that of the TT genotype carriers (Student's t test for
a recessive model: P=0.046). No publication bias was found by using the funnel plot
and Egger's test. CONCLUSION: This meta-analysis suggests a lack of statistical evidence
for the association between the four XPF SNPs and overall risk of cancers. However,
XPF-rs1799801 may be associated with cancer risk in Caucasian populations, which needs
to be further validated in single large, well-designed prospective studies.
Type
Journal articleSubject
HumansNeoplasms
DNA-Binding Proteins
Neoplasm Proteins
Risk Factors
Case-Control Studies
Gene Expression Regulation, Neoplastic
Genotype
Polymorphism, Single Nucleotide
European Continental Ancestry Group
Female
Male
Permalink
https://hdl.handle.net/10161/17981Published Version (Please cite this version)
10.1371/journal.pone.0038606Publication Info
Shi, Ting-Yan; He, Jing; Qiu, Li-Xin; Zhu, Mei-Ling; Wang, Meng-Yun; Zhou, Xiao-Yan;
... Wei, Qingyi (2012). Association between XPF polymorphisms and cancer risk: a meta-analysis. PloS one, 7(7). pp. e38606. 10.1371/journal.pone.0038606. Retrieved from https://hdl.handle.net/10161/17981.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Qingyi Wei
Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director
for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology
and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally
recognized epidemiologist focused on the molecular and genetic epidemiology of head
and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and
genetic determinants for the DNA repair deficient phenotype and

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info