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Association between XPF polymorphisms and cancer risk: a meta-analysis.

dc.contributor.author Wei, Qingyi
dc.contributor.author Shi, Ting-Yan
dc.contributor.author He, Jing
dc.contributor.author Qiu, Li-Xin
dc.contributor.author Zhu, Mei-Ling
dc.contributor.author Wang, Meng-Yun
dc.contributor.author Zhou, Xiao-Yan
dc.contributor.author Han, Jiali
dc.contributor.author Yu, Hongpin
dc.contributor.author Zang, Rong-Yu
dc.date.accessioned 2019-02-01T15:11:03Z
dc.date.available 2019-02-01T15:11:03Z
dc.date.issued 2012-01
dc.identifier PONE-D-12-01707
dc.identifier.issn 1932-6203
dc.identifier.issn 1932-6203
dc.identifier.uri https://hdl.handle.net/10161/17981
dc.description.abstract BACKGROUND: Xeroderma pigmentosum complementation group F (XPF or ERCC4) plays a key role in DNA repair that protects against genetic instability and carcinogenesis. A series of epidemiological studies have examined associations between XPF polymorphisms and cancer risk, but the findings remain inconclusive. METHODOLOGY/PRINCIPAL FINDINGS: In this meta-analysis of 47,639 cancer cases and 51,915 controls, by searching three electronic databases (i.e., MEDLINE, EMBASE and CNKI), we summarized 43 case-control studies from 29 publications on four commonly studied polymorphisms of XPF (i.e., rs1800067, rs1799801, rs2020955 and rs744154), and we did not find statistical evidence of any significant association with overall cancer risk. However, in stratification analyses, we found a significant association of XPF-rs1799801 with a reduced cancer risk in Caucasian populations (4,845 cases and 5,556 controls; recessive model: OR=0.87, 95% CI=0.76-1.00, P=0.049, P=0.723 for heterogeneity test, I(2) =0). Further genotype-phenotype correlation analysis showed that the homozygous variant CC genotype carriers had higher XPF expression levels than that of the TT genotype carriers (Student's t test for a recessive model: P=0.046). No publication bias was found by using the funnel plot and Egger's test. CONCLUSION: This meta-analysis suggests a lack of statistical evidence for the association between the four XPF SNPs and overall risk of cancers. However, XPF-rs1799801 may be associated with cancer risk in Caucasian populations, which needs to be further validated in single large, well-designed prospective studies.
dc.language eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PloS one
dc.relation.isversionof 10.1371/journal.pone.0038606
dc.subject Humans
dc.subject Neoplasms
dc.subject DNA-Binding Proteins
dc.subject Neoplasm Proteins
dc.subject Risk Factors
dc.subject Case-Control Studies
dc.subject Gene Expression Regulation, Neoplastic
dc.subject Genotype
dc.subject Polymorphism, Single Nucleotide
dc.subject European Continental Ancestry Group
dc.subject Female
dc.subject Male
dc.title Association between XPF polymorphisms and cancer risk: a meta-analysis.
dc.type Journal article
dc.date.updated 2019-02-01T15:11:02Z
pubs.begin-page e38606
pubs.issue 7
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Population Health Sciences
pubs.organisational-group Basic Science Departments
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 7
duke.contributor.orcid Wei, Qingyi|0000-0002-3845-9445


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