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Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population.

dc.contributor.author Wei, Qingyi
dc.contributor.author He, Jing
dc.contributor.author Xu, Yu
dc.contributor.author Qiu, Li-Xin
dc.contributor.author Li, Jin
dc.contributor.author Zhou, Xiao-Yan
dc.contributor.author Sun, Meng-Hong
dc.contributor.author Wang, Jiu-Cun
dc.contributor.author Yang, Ya-Jun
dc.contributor.author Jin, Li
dc.contributor.author Wang, Yanong
dc.date.accessioned 2019-02-01T15:12:20Z
dc.date.available 2019-02-01T15:12:20Z
dc.date.issued 2012-01
dc.identifier PONE-D-12-21231
dc.identifier.issn 1932-6203
dc.identifier.issn 1932-6203
dc.identifier.uri https://hdl.handle.net/10161/17987
dc.description.abstract BACKGROUND: Inherited functional single nucleotide polymorphisms (SNPs) in DNA repair genes may alter DNA repair capacity and thus contribute to cancer risk. METHODS: Three ERCC1 functional SNPs (rs2298881C>A, rs3212986C>A and rs11615G>A) and two XPF/ERCC4 functional SNPs (rs2276466C>G and rs6498486A>C) were genotyped for 1125 gastric adenocarcinoma cases and 1196 cancer-free controls by Taqman assays. Odds ratios (OR) and 95% confidence intervals (CI) were used to estimate risk associations, and false-positive report probabilities (FPRP) were calculated for assessing significant findings. RESULTS: ERCC1 rs2298881C and rs11615A variant genotypes were associated with increased gastric cancer risk (adjusted OR=1.33, 95% CI=1.05-1.67 for rs2298881 AC/CC and adjusted OR=1.23, 95% CI=1.05-1.46 for rs11615 AG/AA, compared with their common genotype AA and GG, respectively). Patients with 2-3 ERCC1 risk genotypes had significant increased risk (adjusted OR=1.56, 95% CI=1.27-1.93), compared with those with 0-1 ERCC1 risk genotypes, and this risk was more significantly in subgroups of never drinkers, non-gastric cardia adenocarcinoma (NGCA) and clinical stage I+II. All these risks were not observed for XPF SNPs. CONCLUSIONS: These findings suggest that functional ERCC1 SNPs may contribute to risk of gastric cancer. Larger and well-designed studies with different ethnic populations are needed to validate our findings.
dc.language eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PloS one
dc.relation.isversionof 10.1371/journal.pone.0049308
dc.subject Humans
dc.subject Stomach Neoplasms
dc.subject Endonucleases
dc.subject DNA-Binding Proteins
dc.subject Odds Ratio
dc.subject Risk Factors
dc.subject DNA Repair
dc.subject Genotype
dc.subject Polymorphism, Single Nucleotide
dc.subject Asian Continental Ancestry Group
dc.subject China
dc.title Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population.
dc.type Journal article
dc.date.updated 2019-02-01T15:12:19Z
pubs.begin-page e49308
pubs.issue 11
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Population Health Sciences
pubs.organisational-group Basic Science Departments
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 7
duke.contributor.orcid Wei, Qingyi|0000-0002-3845-9445


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