Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.
Abstract
BACKGROUND: Caspase 7 (CASP7) is an important regulator and executioner in the apoptosis
pathway and plays a crucial role in cancer development and progression. However, few
studies have evaluated associations between functional single nucleotide polymorphisms
(SNPs) in the 3' untranslational region (UTR) of CASP7 and risk of gastric cancer.
METHODS: In a case-control study of 1117 patients with gastric cancer and 1146 cancer-free
controls with frequency matching on age and sex, we genotyped four potentially functional
SNPs (rs4353229T>C, rs10787498T>G, rs1127687G>A and rs12247479G>A) located in the
microRNA binding sites of the CASP7 3' UTR by using Taqman assays and evaluated their
associations with risk of gastric cancer by using logistic regression analyses as
well as multifactorial dimension reduction (MDR) analysis. RESULTS: In the single-locus
analysis, only the CASP7 rs4353229 TT genotype was associated with 0.83-fold decreased
risk (95% confidence interval [CI] = 0.70-0.98) of gastric cancer under a recessive
model, compared with the CT/CC genotypes. In the combined analysis of all four SNPs,
we found that the risk of gastric cancer decreased by 19% in those carrying any of
the risk genotypes (adjusted odds ratio = 0.81, 95% CI = 0.68-0.96), compared with
those carrying zero risk genotypes, and this risk was more evident in subgroups of
younger age (<59 years), females, non-smokers, non-drinkers and patients with non-gastric
cardia adenocarcinoma. Further MDR analysis suggested some evidence of interactions
between the combined genotypes and other risk factors for gastric cancer. CONCLUSIONS:
Potentially functional CASP7 variants may contribute to risk of gastric cancer. Larger
studies with different ethnic populations are warranted to validate our findings.
Type
Journal articleSubject
Cell Line, TransformedHumans
Adenocarcinoma
Stomach Neoplasms
Genetic Predisposition to Disease
RNA, Messenger
Prognosis
Case-Control Studies
Gene Frequency
Gene Order
Genotype
Linkage Disequilibrium
Polymorphism, Single Nucleotide
Alleles
Adult
Aged
Aged, 80 and over
Middle Aged
Asian Continental Ancestry Group
China
Female
Male
Caspase 7
Young Adult
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https://hdl.handle.net/10161/17994Published Version (Please cite this version)
10.1371/journal.pone.0074041Publication Info
Wang, Meng-Yun; Zhu, Mei-Ling; He, Jing; Shi, Ting-Yan; Li, Qiao-Xin; Wang, Ya-Nong;
... Wei, Qing-Yi (2013). Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma
susceptibility in an eastern Chinese population. PloS one, 8(9). pp. e74041. 10.1371/journal.pone.0074041. Retrieved from https://hdl.handle.net/10161/17994.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Qingyi Wei
Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director
for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology
and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally
recognized epidemiologist focused on the molecular and genetic epidemiology of head
and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and
genetic determinants for the DNA repair deficient phenotype and

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