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Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.

dc.contributor.author Wei, Qingyi
dc.contributor.author Wang, Meng-Yun
dc.contributor.author Zhu, Mei-Ling
dc.contributor.author He, Jing
dc.contributor.author Shi, Ting-Yan
dc.contributor.author Li, Qiao-Xin
dc.contributor.author Wang, Ya-Nong
dc.contributor.author Li, Jin
dc.contributor.author Zhou, Xiao-Yan
dc.contributor.author Sun, Meng-Hong
dc.contributor.author Wang, Xiao-Feng
dc.contributor.author Yang, Ya-Jun
dc.contributor.author Wang, Jiu-Cun
dc.contributor.author Jin, Li
dc.date.accessioned 2019-02-01T15:14:42Z
dc.date.available 2019-02-01T15:14:42Z
dc.date.issued 2013-01
dc.identifier PONE-D-13-23939
dc.identifier.issn 1932-6203
dc.identifier.issn 1932-6203
dc.identifier.uri https://hdl.handle.net/10161/17994
dc.description.abstract BACKGROUND: Caspase 7 (CASP7) is an important regulator and executioner in the apoptosis pathway and plays a crucial role in cancer development and progression. However, few studies have evaluated associations between functional single nucleotide polymorphisms (SNPs) in the 3' untranslational region (UTR) of CASP7 and risk of gastric cancer. METHODS: In a case-control study of 1117 patients with gastric cancer and 1146 cancer-free controls with frequency matching on age and sex, we genotyped four potentially functional SNPs (rs4353229T>C, rs10787498T>G, rs1127687G>A and rs12247479G>A) located in the microRNA binding sites of the CASP7 3' UTR by using Taqman assays and evaluated their associations with risk of gastric cancer by using logistic regression analyses as well as multifactorial dimension reduction (MDR) analysis. RESULTS: In the single-locus analysis, only the CASP7 rs4353229 TT genotype was associated with 0.83-fold decreased risk (95% confidence interval [CI] = 0.70-0.98) of gastric cancer under a recessive model, compared with the CT/CC genotypes. In the combined analysis of all four SNPs, we found that the risk of gastric cancer decreased by 19% in those carrying any of the risk genotypes (adjusted odds ratio = 0.81, 95% CI = 0.68-0.96), compared with those carrying zero risk genotypes, and this risk was more evident in subgroups of younger age (<59 years), females, non-smokers, non-drinkers and patients with non-gastric cardia adenocarcinoma. Further MDR analysis suggested some evidence of interactions between the combined genotypes and other risk factors for gastric cancer. CONCLUSIONS: Potentially functional CASP7 variants may contribute to risk of gastric cancer. Larger studies with different ethnic populations are warranted to validate our findings.
dc.language eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PloS one
dc.relation.isversionof 10.1371/journal.pone.0074041
dc.subject Cell Line, Transformed
dc.subject Humans
dc.subject Adenocarcinoma
dc.subject Stomach Neoplasms
dc.subject Genetic Predisposition to Disease
dc.subject RNA, Messenger
dc.subject Prognosis
dc.subject Case-Control Studies
dc.subject Gene Frequency
dc.subject Gene Order
dc.subject Genotype
dc.subject Linkage Disequilibrium
dc.subject Polymorphism, Single Nucleotide
dc.subject Alleles
dc.subject Adult
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Middle Aged
dc.subject Asian Continental Ancestry Group
dc.subject China
dc.subject Female
dc.subject Male
dc.subject Caspase 7
dc.subject Young Adult
dc.title Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.
dc.type Journal article
dc.date.updated 2019-02-01T15:14:41Z
pubs.begin-page e74041
pubs.issue 9
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Population Health Sciences
pubs.organisational-group Basic Science Departments
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 8
duke.contributor.orcid Wei, Qingyi|0000-0002-3845-9445


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