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Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.

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Date
2014-01
Authors
Zhang, Junjie
Huang, Xuewen
Xiao, Juanjuan
Yang, Yajun
Zhou, Yinghui
Wang, Xiaofeng
Liu, Qingmei
Yang, Jingmin
Wang, Mengyun
Qiu, Lixin
Zheng, Yabiao
Zhang, Ping
Li, Jin
Wang, Ya'nong
Wei, Qingyi
Jin, Li
Wang, Jiucun
Wang, Minghua
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(18 total)
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Abstract
MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1, rs895819/pre-miR-27a, and rs11134527/pri-miR-218 were reported to be associated with risks of various cancers. In order to evaluate the relationship of these SNPs and esophageal squamous cell carcinoma (ESCC) risk, we conducted a case-control study with 1109 ESCC patients and 1275 control subjects to examine the potential association of these pri/pre-miRNA polymorphisms with ESCC susceptibility. As a result, two SNPs were associated with a significant risk of ESCC. We found that the GG genotype of pri-miR-124-1 rs531564 was associated to a significantly decreased risk of ESCC comparing with the CC/CG genotypes (p = 0.005; OR = 0.61, 95% CI = 0.43-0.86). In addition, the CC genotype of pri-miR-34b/c rs4938723 was associated with a significant decreased risk of ESCC (CC VS.p = 0.007, OR = 0.82, 95% CI = 0.71-0.95) in Chinese population. The present study provides the first evidence that pri-miR-124-1 rs531564 and pri-miR-34 rs4938723 were associated with the risk of ESCC in Chinese population.
Type
Journal article
Subject
Humans
Carcinoma, Squamous Cell
Esophageal Neoplasms
Genetic Predisposition to Disease
MicroRNAs
Risk Factors
Case-Control Studies
Alcohol Drinking
Smoking
Polymorphism, Single Nucleotide
Adult
Aged
Aged, 80 and over
Middle Aged
Asian Continental Ancestry Group
China
Female
Male
Genetic Association Studies
Multifactor Dimensionality Reduction
Permalink
https://hdl.handle.net/10161/17999
Published Version (Please cite this version)
10.1371/journal.pone.0100055
Publication Info
Zhang, Junjie; Huang, Xuewen; Xiao, Juanjuan; Yang, Yajun; Zhou, Yinghui; Wang, Xiaofeng; ... Wang, Minghua (2014). Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations. PloS one, 9(6). pp. e100055. 10.1371/journal.pone.0100055. Retrieved from https://hdl.handle.net/10161/17999.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Wei

Qingyi Wei

Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally recognized epidemiologist focused on the molecular and genetic epidemiology of head and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and genetic determinants for the DNA repair deficient phenotype and
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