Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.
Abstract
MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function
as tumor suppressors or oncogenes. Aberrant expression and structural alteration of
microRNAs have been reported to be involved in tumorigenesis and cancer development.
Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1,
rs895819/pre-miR-27a, and rs11134527/pri-miR-218 were reported to be associated with
risks of various cancers. In order to evaluate the relationship of these SNPs and
esophageal squamous cell carcinoma (ESCC) risk, we conducted a case-control study
with 1109 ESCC patients and 1275 control subjects to examine the potential association
of these pri/pre-miRNA polymorphisms with ESCC susceptibility. As a result, two SNPs
were associated with a significant risk of ESCC. We found that the GG genotype of
pri-miR-124-1 rs531564 was associated to a significantly decreased risk of ESCC comparing
with the CC/CG genotypes (p = 0.005; OR = 0.61, 95% CI = 0.43-0.86). In addition,
the CC genotype of pri-miR-34b/c rs4938723 was associated with a significant decreased
risk of ESCC (CC VS.p = 0.007, OR = 0.82, 95% CI = 0.71-0.95) in Chinese population.
The present study provides the first evidence that pri-miR-124-1 rs531564 and pri-miR-34
rs4938723 were associated with the risk of ESCC in Chinese population.
Type
Journal articleSubject
HumansCarcinoma, Squamous Cell
Esophageal Neoplasms
Genetic Predisposition to Disease
MicroRNAs
Risk Factors
Case-Control Studies
Alcohol Drinking
Smoking
Polymorphism, Single Nucleotide
Adult
Aged
Aged, 80 and over
Middle Aged
Asian Continental Ancestry Group
China
Female
Male
Genetic Association Studies
Multifactor Dimensionality Reduction
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https://hdl.handle.net/10161/17999Published Version (Please cite this version)
10.1371/journal.pone.0100055Publication Info
Zhang, Junjie; Huang, Xuewen; Xiao, Juanjuan; Yang, Yajun; Zhou, Yinghui; Wang, Xiaofeng;
... Wang, Minghua (2014). Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with
decreased risk of esophageal squamous cell carcinoma in Chinese populations. PloS one, 9(6). pp. e100055. 10.1371/journal.pone.0100055. Retrieved from https://hdl.handle.net/10161/17999.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Qingyi Wei
Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director
for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology
and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally
recognized epidemiologist focused on the molecular and genetic epidemiology of head
and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and
genetic determinants for the DNA repair deficient phenotype and

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