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    Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.

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    Date
    2014-01
    Authors
    Wei, Qingyi
    Zhang, Junjie
    Huang, Xuewen
    Xiao, Juanjuan
    Yang, Yajun
    Zhou, Yinghui
    Wang, Xiaofeng
    Liu, Qingmei
    Yang, Jingmin
    Wang, Mengyun
    Qiu, Lixin
    Zheng, Yabiao
    Zhang, Ping
    Li, Jin
    Wang, Ya'nong
    Jin, Li
    Wang, Jiucun
    Wang, Minghua
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    Abstract
    MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1, rs895819/pre-miR-27a, and rs11134527/pri-miR-218 were reported to be associated with risks of various cancers. In order to evaluate the relationship of these SNPs and esophageal squamous cell carcinoma (ESCC) risk, we conducted a case-control study with 1109 ESCC patients and 1275 control subjects to examine the potential association of these pri/pre-miRNA polymorphisms with ESCC susceptibility. As a result, two SNPs were associated with a significant risk of ESCC. We found that the GG genotype of pri-miR-124-1 rs531564 was associated to a significantly decreased risk of ESCC comparing with the CC/CG genotypes (p = 0.005; OR = 0.61, 95% CI = 0.43-0.86). In addition, the CC genotype of pri-miR-34b/c rs4938723 was associated with a significant decreased risk of ESCC (CC VS.p = 0.007, OR = 0.82, 95% CI = 0.71-0.95) in Chinese population. The present study provides the first evidence that pri-miR-124-1 rs531564 and pri-miR-34 rs4938723 were associated with the risk of ESCC in Chinese population.
    Type
    Journal article
    Subject
    Humans
    Carcinoma, Squamous Cell
    Esophageal Neoplasms
    Genetic Predisposition to Disease
    MicroRNAs
    Risk Factors
    Case-Control Studies
    Alcohol Drinking
    Smoking
    Polymorphism, Single Nucleotide
    Adult
    Aged
    Aged, 80 and over
    Middle Aged
    Asian Continental Ancestry Group
    China
    Female
    Male
    Genetic Association Studies
    Multifactor Dimensionality Reduction
    Permalink
    https://hdl.handle.net/10161/17999
    Published Version (Please cite this version)
    10.1371/journal.pone.0100055
    Publication Info
    Wei, Qingyi; Zhang, Junjie; Huang, Xuewen; Xiao, Juanjuan; Yang, Yajun; Zhou, Yinghui; ... Wang, Minghua (2014). Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations. PloS one, 9(6). pp. e100055. 10.1371/journal.pone.0100055. Retrieved from https://hdl.handle.net/10161/17999.
    This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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    Scholars@Duke

    Wei

    Qingyi Wei

    Professor in Population Health Sciences
    Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally recognized epidemiologist focused on the molecular and genetic epidemiology of head and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and genetic determinants for the DNA repair deficient phenotype and
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    Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy

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