dc.contributor.author |
Wei, Qingyi |
|
dc.contributor.author |
Qiu, Li-Xin |
|
dc.contributor.author |
Hua, Rui-Xi |
|
dc.contributor.author |
Cheng, Lei |
|
dc.contributor.author |
He, Jing |
|
dc.contributor.author |
Wang, Meng-Yun |
|
dc.contributor.author |
Zhou, Fei |
|
dc.contributor.author |
Zhu, Xiao-Dong |
|
dc.contributor.author |
Sun, Meng-Hong |
|
dc.contributor.author |
Zhou, Xiao-Yan |
|
dc.contributor.author |
Li, Jin |
|
dc.contributor.author |
Wang, Ya-Nong |
|
dc.contributor.author |
Yang, Ya-Jun |
|
dc.contributor.author |
Wang, Jiu-Cun |
|
dc.contributor.author |
Jin, Li |
|
dc.contributor.author |
Guo, Wei-Jian |
|
dc.date.accessioned |
2019-02-01T15:23:27Z |
|
dc.date.available |
2019-02-01T15:23:27Z |
|
dc.date.issued |
2016-03 |
|
dc.identifier |
7527 |
|
dc.identifier.issn |
1949-2553 |
|
dc.identifier.issn |
1949-2553 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/18007 |
|
dc.description.abstract |
Published data on the association between the MUC1 rs4072037A > G polymorphism and
gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of
the association, we conducted a large GCa study of 1,124 cases and 1,192 controls
to confirm this association in an Eastern Chinese population. Our results showed that
the G allele was strongly associated with a decreased GCa risk in the study population
[GG vs. AA, odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.31-0.73; AG/GG
vs. AA, OR = 0.82, 95% CI = 0.68-0.99; GG vs. AA/AG, OR = 0.48, 95% CI = 0.32-0.74].
These associations remained significant in subgroups of age, tumor site, drinking
and smoking status. Moreover, this association was supported by an additional meta-analysis
of published studies. In summary, these results suggest that the MUC1 rs4072037G allele
may be a low-penetrating protection factor for GCa risk in Chinese populations.
|
|
dc.language |
eng |
|
dc.publisher |
Impact Journals, LLC |
|
dc.relation.ispartof |
Oncotarget |
|
dc.relation.isversionof |
10.18632/oncotarget.7527 |
|
dc.subject |
Humans |
|
dc.subject |
Adenocarcinoma |
|
dc.subject |
Stomach Neoplasms |
|
dc.subject |
Genetic Predisposition to Disease |
|
dc.subject |
Odds Ratio |
|
dc.subject |
Risk Factors |
|
dc.subject |
Genotype |
|
dc.subject |
Polymorphism, Single Nucleotide |
|
dc.subject |
Adult |
|
dc.subject |
Aged |
|
dc.subject |
Middle Aged |
|
dc.subject |
Asian Continental Ancestry Group |
|
dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
Mucin-1 |
|
dc.title |
Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population. |
|
dc.type |
Journal article |
|
dc.date.updated |
2019-02-01T15:23:22Z |
|
pubs.begin-page |
15930 |
|
pubs.end-page |
15936 |
|
pubs.issue |
13 |
|
pubs.organisational-group |
School of Medicine |
|
pubs.organisational-group |
Duke |
|
pubs.organisational-group |
Duke Cancer Institute |
|
pubs.organisational-group |
Institutes and Centers |
|
pubs.organisational-group |
Population Health Sciences |
|
pubs.organisational-group |
Basic Science Departments |
|
pubs.organisational-group |
Medicine, Medical Oncology |
|
pubs.organisational-group |
Medicine |
|
pubs.organisational-group |
Clinical Science Departments |
|
pubs.publication-status |
Published |
|
pubs.volume |
7 |
|
duke.contributor.orcid |
Wei, Qingyi|0000-0002-3845-9445 |
|