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Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.

dc.contributor.author Wei, Qingyi
dc.contributor.author Qiu, Li-Xin
dc.contributor.author Hua, Rui-Xi
dc.contributor.author Cheng, Lei
dc.contributor.author He, Jing
dc.contributor.author Wang, Meng-Yun
dc.contributor.author Zhou, Fei
dc.contributor.author Zhu, Xiao-Dong
dc.contributor.author Sun, Meng-Hong
dc.contributor.author Zhou, Xiao-Yan
dc.contributor.author Li, Jin
dc.contributor.author Wang, Ya-Nong
dc.contributor.author Yang, Ya-Jun
dc.contributor.author Wang, Jiu-Cun
dc.contributor.author Jin, Li
dc.contributor.author Guo, Wei-Jian
dc.date.accessioned 2019-02-01T15:23:27Z
dc.date.available 2019-02-01T15:23:27Z
dc.date.issued 2016-03
dc.identifier 7527
dc.identifier.issn 1949-2553
dc.identifier.issn 1949-2553
dc.identifier.uri https://hdl.handle.net/10161/18007
dc.description.abstract Published data on the association between the MUC1 rs4072037A > G polymorphism and gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of the association, we conducted a large GCa study of 1,124 cases and 1,192 controls to confirm this association in an Eastern Chinese population. Our results showed that the G allele was strongly associated with a decreased GCa risk in the study population [GG vs. AA, odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.31-0.73; AG/GG vs. AA, OR = 0.82, 95% CI = 0.68-0.99; GG vs. AA/AG, OR = 0.48, 95% CI = 0.32-0.74]. These associations remained significant in subgroups of age, tumor site, drinking and smoking status. Moreover, this association was supported by an additional meta-analysis of published studies. In summary, these results suggest that the MUC1 rs4072037G allele may be a low-penetrating protection factor for GCa risk in Chinese populations.
dc.language eng
dc.publisher Impact Journals, LLC
dc.relation.ispartof Oncotarget
dc.relation.isversionof 10.18632/oncotarget.7527
dc.subject Humans
dc.subject Adenocarcinoma
dc.subject Stomach Neoplasms
dc.subject Genetic Predisposition to Disease
dc.subject Odds Ratio
dc.subject Risk Factors
dc.subject Genotype
dc.subject Polymorphism, Single Nucleotide
dc.subject Adult
dc.subject Aged
dc.subject Middle Aged
dc.subject Asian Continental Ancestry Group
dc.subject Female
dc.subject Male
dc.subject Mucin-1
dc.title Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.
dc.type Journal article
duke.contributor.id Wei, Qingyi|0632334
dc.date.updated 2019-02-01T15:23:22Z
pubs.begin-page 15930
pubs.end-page 15936
pubs.issue 13
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Population Health Sciences
pubs.organisational-group Basic Science Departments
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 7
duke.contributor.orcid Wei, Qingyi|0000-0002-3845-9445


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