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Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives.

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Date
2018-03
Authors
deSouza, NM
Winfield, JM
Waterton, JC
Weller, A
Papoutsaki, M-V
Doran, SJ
Collins, DJ
Fournier, L
Sullivan, D
Chenevert, T
Jackson, A
Boss, M
Trattnig, S
Liu, Y
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(14 total)
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Abstract
For body imaging, diffusion-weighted MRI may be used for tumour detection, staging, prognostic information, assessing response and follow-up. Disease detection and staging involve qualitative, subjective assessment of images, whereas for prognosis, progression or response, quantitative evaluation of the apparent diffusion coefficient (ADC) is required. Validation and qualification of ADC in multicentre trials involves examination of i) technical performance to determine biomarker bias and reproducibility and ii) biological performance to interrogate a specific aspect of biology or to forecast outcome. Unfortunately, the variety of acquisition and analysis methodologies employed at different centres make ADC values non-comparable between them. This invalidates implementation in multicentre trials and limits utility of ADC as a biomarker. This article reviews the factors contributing to ADC variability in terms of data acquisition and analysis. Hardware and software considerations are discussed when implementing standardised protocols across multi-vendor platforms together with methods for quality assurance and quality control. Processes of data collection, archiving, curation, analysis, central reading and handling incidental findings are considered in the conduct of multicentre trials. Data protection and good clinical practice are essential prerequisites. Developing international consensus of procedures is critical to successful validation if ADC is to become a useful biomarker in oncology.• Standardised acquisition/analysis allows quantification of imaging biomarkers in multicentre trials. • Establishing "precision" of the measurement in the multicentre context is essential. • A repository with traceable data of known provenance promotes further research.
Type
Journal article
Subject
Humans
Neoplasms
Disease Progression
Diffusion Magnetic Resonance Imaging
Prognosis
Prospective Studies
Reproducibility of Results
Software
Quality Assurance, Health Care
Multicenter Studies as Topic
Healthy Volunteers
Permalink
https://hdl.handle.net/10161/18008
Published Version (Please cite this version)
10.1007/s00330-017-4972-z
Publication Info
deSouza, NM; Winfield, JM; Waterton, JC; Weller, A; Papoutsaki, M-V; Doran, SJ; ... Liu, Y (2018). Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives. European radiology, 28(3). pp. 1118-1131. 10.1007/s00330-017-4972-z. Retrieved from https://hdl.handle.net/10161/18008.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Sullivan

Daniel Carl Sullivan

Professor Emeritus of Radiology
Research interests are in oncologic imaging, especially the clinical evaluation and validation of imaging biomarkers for therapeutic response assessment.
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