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TNF rs1799964 as a Predictive Factor of Acute Toxicities in Chinese Rectal Cancer Patients Treated With Chemoradiotherapy.

dc.contributor.author Wei, Qingyi
dc.contributor.author Zhang, Hui
dc.contributor.author Wang, Mengyun
dc.contributor.author Shi, Tingyan
dc.contributor.author Shen, Lijun
dc.contributor.author Liang, Liping
dc.contributor.author Deng, Yun
dc.contributor.author Li, Guichao
dc.contributor.author Zhu, Ji
dc.contributor.author Wu, Yongxin
dc.contributor.author Fan, Ming
dc.contributor.author Deng, Weijuan
dc.contributor.author Zhang, Zhen
dc.date.accessioned 2019-02-01T15:24:04Z
dc.date.available 2019-02-01T15:24:04Z
dc.date.issued 2015-11
dc.identifier 00005792-201511110-00024
dc.identifier.issn 0025-7974
dc.identifier.issn 1536-5964
dc.identifier.uri https://hdl.handle.net/10161/18010
dc.description.abstract Acute toxicity is the main dose-limiting factor in the chemoradiotherapy of rectal cancer patients and depends on several pro-inflammatory factors, including interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-α). It is unknown whether genetic factors, such as single-nucleotide polymorphisms (SNPs) in the IL-1, IL-6, and TNF genes, are also associated with acute toxicity in the process.We genotyped 5 potentially functional SNPs in these 3 genes (TNF rs1799964, TNF rs1800629, IL-6 rs1800796, and IL-1 rs1143623, IL-1 rs1143627) and estimated their associations with severe acute radiation injury (grade ≥2) in 356 rectal cancer patients.We found a predictive role of the TNF rs1799964 T variant allele in the development of acute injury (for CT vs CC: adjusted odds ratio [OR] = 4.718, 95% confidence interval [CI] = 1.152-19.328, P = 0.031; for TT vs CC: adjusted OR = 4.443, 95% CI = 1.123-17.581, P = 0.034). In the dominant model, for CT/TT vs CC, the adjusted OR = 4.132, 95% CI = 1.069-15.966, and P = 0.04.Our results suggested that genetic variants in the TNF gene may influence acute injury in rectal cancer patients treated with chemoradiotherapy and may be a predictor for personalized treatment. Additional larger and independent studies are needed to confirm our findings.
dc.language eng
dc.publisher Ovid Technologies (Wolters Kluwer Health)
dc.relation.ispartof Medicine
dc.relation.isversionof 10.1097/MD.0000000000001955
dc.subject Cell Line, Tumor
dc.subject Humans
dc.subject Adenocarcinoma
dc.subject Rectal Neoplasms
dc.subject Tumor Necrosis Factor-alpha
dc.subject Interleukin-1
dc.subject Interleukin-6
dc.subject Genotype
dc.subject Adolescent
dc.subject Adult
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Middle Aged
dc.subject Female
dc.subject Male
dc.subject Young Adult
dc.subject Chemoradiotherapy
dc.title TNF rs1799964 as a Predictive Factor of Acute Toxicities in Chinese Rectal Cancer Patients Treated With Chemoradiotherapy.
dc.type Journal article
dc.date.updated 2019-02-01T15:24:00Z
pubs.begin-page e1955
pubs.issue 45
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Population Health Sciences
pubs.organisational-group Basic Science Departments
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 94
duke.contributor.orcid Wei, Qingyi|0000-0002-3845-9445


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