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PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.

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Date
2016-02
Authors
Qiu, Li-Xin
Cheng, Lei
He, Jing
Zhou, Zhi-Rui
Wang, Meng-Yun
Zhou, Fei
Guo, Wei-Jian
Li, Jin
Sun, Meng-Hong
Zhou, Xiao-Yan
Wang, Ya-Nong
Yang, Ya-Jun
Wang, Jiu-Cun
Jin, Li
Zhu, Xiao-Dong
Wei, Qing-Yi
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(16 total)
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Abstract
The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. The associations between the PSCA rs2294008 and rs2976392 single nucleotide polymorphisms (SNPs) and gastric cancer (GCa) susceptibility were still controversial. To derive a more precise estimation of the associations, we conducted a case-control study of 1,124 cases and 1,192 controls in an eastern Chinese population. We found that the rs2294008T variant genotypes were associated with an increased GCa risk in this study population (CT vs CC, OR=1.59, 95% CI=1.33-1.89 and CT+TT vs CC, OR=1.38, 95% CI=1.17-1.62). For SNP rs2976392, the variant A genotypes were also associated with an increased GCa risk (AG vs GG, OR=1.61, 95% CI=1.35-1.91 and AG+AA vs GG, OR=1.47, 95% CI=1.25-1.74). The results were further validated by a meta-analysis. In conclusion, the results indicated that the PSCA rs2294008 T and rs2976392 A alleles were low-penetrate risk factors for GCa in this study population. However, large and well-designed studies are warranted to validate our findings.
Type
Journal article
Subject
Humans
Stomach Neoplasms
Genetic Predisposition to Disease
Prostate-Specific Antigen
Neoplasm Proteins
Antigens, Neoplasm
Risk Factors
Case-Control Studies
Cell Adhesion
Cell Proliferation
Gene Frequency
Polymorphism, Single Nucleotide
Middle Aged
Asian Continental Ancestry Group
China
Female
Male
GPI-Linked Proteins
Permalink
https://hdl.handle.net/10161/18012
Published Version (Please cite this version)
10.18632/oncotarget.7137
Publication Info
Qiu, Li-Xin; Cheng, Lei; He, Jing; Zhou, Zhi-Rui; Wang, Meng-Yun; Zhou, Fei; ... Wei, Qing-Yi (2016). PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population. Oncotarget, 7(8). pp. 9420-9428. 10.18632/oncotarget.7137. Retrieved from https://hdl.handle.net/10161/18012.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Wei

Qingyi Wei

Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally recognized epidemiologist focused on the molecular and genetic epidemiology of head and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and genetic determinants for the DNA repair deficient phenotype and

Fei Zhou

Visiting Scholar in the Department of Medicine
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
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