PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.
Abstract
The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen
(PSA), was identified as a gene involved in cell adhesion and proliferation. The associations
between the PSCA rs2294008 and rs2976392 single nucleotide polymorphisms (SNPs) and
gastric cancer (GCa) susceptibility were still controversial. To derive a more precise
estimation of the associations, we conducted a case-control study of 1,124 cases and
1,192 controls in an eastern Chinese population. We found that the rs2294008T variant
genotypes were associated with an increased GCa risk in this study population (CT
vs CC, OR=1.59, 95% CI=1.33-1.89 and CT+TT vs CC, OR=1.38, 95% CI=1.17-1.62). For
SNP rs2976392, the variant A genotypes were also associated with an increased GCa
risk (AG vs GG, OR=1.61, 95% CI=1.35-1.91 and AG+AA vs GG, OR=1.47, 95% CI=1.25-1.74).
The results were further validated by a meta-analysis. In conclusion, the results
indicated that the PSCA rs2294008 T and rs2976392 A alleles were low-penetrate risk
factors for GCa in this study population. However, large and well-designed studies
are warranted to validate our findings.
Type
Journal articleSubject
HumansStomach Neoplasms
Genetic Predisposition to Disease
Prostate-Specific Antigen
Neoplasm Proteins
Antigens, Neoplasm
Risk Factors
Case-Control Studies
Cell Adhesion
Cell Proliferation
Gene Frequency
Polymorphism, Single Nucleotide
Middle Aged
Asian Continental Ancestry Group
China
Female
Male
GPI-Linked Proteins
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https://hdl.handle.net/10161/18012Published Version (Please cite this version)
10.18632/oncotarget.7137Publication Info
Qiu, Li-Xin; Cheng, Lei; He, Jing; Zhou, Zhi-Rui; Wang, Meng-Yun; Zhou, Fei; ... Wei,
Qing-Yi (2016). PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.
Oncotarget, 7(8). pp. 9420-9428. 10.18632/oncotarget.7137. Retrieved from https://hdl.handle.net/10161/18012.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Qingyi Wei
Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director
for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology
and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally
recognized epidemiologist focused on the molecular and genetic epidemiology of head
and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and
genetic determinants for the DNA repair deficient phenotype and
Fei Zhou
Visiting Scholar in the Department of Medicine
This author no longer has a Scholars@Duke profile, so the information shown here reflects
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