Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.
Abstract
Cell cycle deregulation is common in human cancer, and alterations of p27 and p21,
two critical cell cycle regulators, have been implicated in the development of many
human malignancies. Therefore, we hypothesize that p27 T109G polymorphism individually
or in combination with p21 (C98A and C70T) polymorphisms modifies risk of second primary
malignancy (SPM) in patients with index squamous cell carcinoma of head and neck (SCCHN).A
cohort of 1,292 patients with index SCCHN was recruited between May 1995 and January
2007 at the M.D. Anderson Cancer Center and followed for SPM occurrence. Patients
were genotyped for the three polymorphisms. A log-rank test and Cox proportional hazards
models were used to compare SPM-free survival and SPM risk.We found that patients
with p27 109 TG/GG, p21 98 CA/AA and p21 70 CT/TT variant genotypes had a worse SPM-free
survival and an increased SPM risk than those with the corresponding p27109 TT, p21
98 CC, and p21 70 CC common genotypes, respectively. After combining the three polymorphisms,
there was a trend for significantly increased SPM risk with increasing number of the
variant genotypes (Ptrend = 0.0002). Moreover, patients with the variant genotypes
had an approximately 2.4-fold significantly increased risk for SPM compared with those
with no variant genotypes (HR, 2.4, 95% CI, 1.6-3.6).These results suggest that p27
T109G polymorphism individually or in combination with p21 (C98A and C70T) polymorphisms
increases risk of SPM in patients with index SCCHN.
Type
Journal articleSubject
HumansCarcinoma, Squamous Cell
Head and Neck Neoplasms
Neoplasms, Second Primary
Genetic Predisposition to Disease
Genotype
Polymorphism, Genetic
Middle Aged
Female
Male
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Permalink
https://hdl.handle.net/10161/18020Published Version (Please cite this version)
10.1186/1476-4598-11-17Publication Info
Wang, Zhongqiu; Sturgis, Erich M; Zhang, Fenghua; Lei, Dapeng; Liu, Zhensheng; Xu,
Li; ... Li, Guojun (2012). Genetic variants of p27 and p21 as predictors for risk of second primary malignancy
in patients with index squamous cell carcinoma of head and neck. Molecular cancer, 11(1). pp. 17. 10.1186/1476-4598-11-17. Retrieved from https://hdl.handle.net/10161/18020.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Zhensheng Liu
Assistant Professor of Medicine
Qingyi Wei
Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director
for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology
and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally
recognized epidemiologist focused on the molecular and genetic epidemiology of head
and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and
genetic determinants for the DNA repair deficient phenotype and
Alphabetical list of authors with Scholars@Duke profiles.

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info