Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.
Abstract
FAS/FASL promoter variants are considered in altering transcriptional activity of
those genes and consequently alter regulation of cell death. However, no studies have
investigated whether tumor sites contribute to the association between FAS/FASL polymorphisms
and risk for second primary malignancy (SPM).In this study, FAS670 A > G, FAS1377
G > A, FASL124 A > G, and FASL844C > T polymorphisms were genotyped in 752 OPC and
777 non-OPC patients. Both univariate and multivariable cox proportional hazard models
were used to assess the associations.The univariate and multivariable analyses showed
that patients with index OPC and FASL844 CT/TT genotype had significantly increased
risk of SPM (cHR, 2.5; 95% CI, 1.1-5.8, P = 0.043 and aHR, 2.7; 95% CI, 1.2-6.0, P
= 0.032) compared with those with FASL844 CC genotype as the reference group, while
index non-OPC patients with FAS670 AG/GG and FasL844 CT/TT genotypes had significantly
increased risk of SPM (cHR, 2.2 and 1.8; 95% CI, 1.2-5.7 and 1.1-3.2; and P = 0.04
and 0.041, respectively and aHR, 2.4 and 1.7; 95% CI, 1.1-5.1 and 1.0-3.0; and P =
0.043 and 0.049, respectively) compared with their corresponding AA and CC genotypes
. Moreover, patients carrying more FAS/FASL variants significantly increased risk
of SPM among index non-OPC patients. The stratified analysis showed that smoking status
differently modified the associations between FAS/FASL polymorphisms and risk of SPM
among index non-OPC from OPC patients.These results suggested that FAS/FASL polymorphisms
might significantly modify SPM risk among patients with SCCHN in a tumor site-specific
manner.
Type
Journal articleSubject
HumansCarcinoma, Squamous Cell
Head and Neck Neoplasms
Neoplasms, Second Primary
Antigens, CD95
Proportional Hazards Models
Risk Factors
Apoptosis
Polymorphism, Genetic
Aged
Middle Aged
Female
Male
Fas Ligand Protein
Promoter Regions, Genetic
Genetic Association Studies
Permalink
https://hdl.handle.net/10161/18026Published Version (Please cite this version)
10.1186/s12885-016-2110-yPublication Info
Sun, Yan; Yu, Wenbin; Sturgis, Erich M; Peng, Wei; Lei, Dapeng; Wei, Qingyi; ... Li,
Guojun (2016). Site disparities in apoptotic variants as predictors of risk for second primary malignancy
in patients with squamous cell carcinoma of the head and neck. BMC cancer, 16(1). pp. 70. 10.1186/s12885-016-2110-y. Retrieved from https://hdl.handle.net/10161/18026.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Qingyi Wei
Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director
for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology
and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally
recognized epidemiologist focused on the molecular and genetic epidemiology of head
and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and
genetic determinants for the DNA repair deficient phenotype and

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info