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Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.

dc.contributor.author Wei, Qingyi
dc.contributor.author Sun, Yan
dc.contributor.author Yu, Wenbin
dc.contributor.author Sturgis, Erich M
dc.contributor.author Peng, Wei
dc.contributor.author Lei, Dapeng
dc.contributor.author Song, Xicheng
dc.contributor.author Li, Guojun
dc.date.accessioned 2019-02-01T15:28:26Z
dc.date.available 2019-02-01T15:28:26Z
dc.date.issued 2016-02-08
dc.identifier 10.1186/s12885-016-2110-y
dc.identifier.issn 1471-2407
dc.identifier.issn 1471-2407
dc.identifier.uri https://hdl.handle.net/10161/18026
dc.description.abstract FAS/FASL promoter variants are considered in altering transcriptional activity of those genes and consequently alter regulation of cell death. However, no studies have investigated whether tumor sites contribute to the association between FAS/FASL polymorphisms and risk for second primary malignancy (SPM).In this study, FAS670 A > G, FAS1377 G > A, FASL124 A > G, and FASL844C > T polymorphisms were genotyped in 752 OPC and 777 non-OPC patients. Both univariate and multivariable cox proportional hazard models were used to assess the associations.The univariate and multivariable analyses showed that patients with index OPC and FASL844 CT/TT genotype had significantly increased risk of SPM (cHR, 2.5; 95% CI, 1.1-5.8, P = 0.043 and aHR, 2.7; 95% CI, 1.2-6.0, P = 0.032) compared with those with FASL844 CC genotype as the reference group, while index non-OPC patients with FAS670 AG/GG and FasL844 CT/TT genotypes had significantly increased risk of SPM (cHR, 2.2 and 1.8; 95% CI, 1.2-5.7 and 1.1-3.2; and P = 0.04 and 0.041, respectively and aHR, 2.4 and 1.7; 95% CI, 1.1-5.1 and 1.0-3.0; and P = 0.043 and 0.049, respectively) compared with their corresponding AA and CC genotypes . Moreover, patients carrying more FAS/FASL variants significantly increased risk of SPM among index non-OPC patients. The stratified analysis showed that smoking status differently modified the associations between FAS/FASL polymorphisms and risk of SPM among index non-OPC from OPC patients.These results suggested that FAS/FASL polymorphisms might significantly modify SPM risk among patients with SCCHN in a tumor site-specific manner.
dc.language eng
dc.publisher Springer Nature
dc.relation.ispartof BMC cancer
dc.relation.isversionof 10.1186/s12885-016-2110-y
dc.subject Humans
dc.subject Carcinoma, Squamous Cell
dc.subject Head and Neck Neoplasms
dc.subject Neoplasms, Second Primary
dc.subject Antigens, CD95
dc.subject Proportional Hazards Models
dc.subject Risk Factors
dc.subject Apoptosis
dc.subject Polymorphism, Genetic
dc.subject Aged
dc.subject Middle Aged
dc.subject Female
dc.subject Male
dc.subject Fas Ligand Protein
dc.subject Promoter Regions, Genetic
dc.subject Genetic Association Studies
dc.title Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.
dc.type Journal article
dc.date.updated 2019-02-01T15:28:23Z
pubs.begin-page 70
pubs.issue 1
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Population Health Sciences
pubs.organisational-group Basic Science Departments
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 16
duke.contributor.orcid Wei, Qingyi|0000-0002-3845-9445


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