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Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck.

dc.contributor.author Liu, Zhensheng
dc.contributor.author Wei, Qingyi
dc.contributor.author Ma, Hongxia
dc.contributor.author Wang, Li-E
dc.contributor.author Sturgis, Erich M
dc.date.accessioned 2019-02-01T15:29:02Z
dc.date.available 2019-02-01T15:29:02Z
dc.date.issued 2011-06-20
dc.identifier 1471-2407-11-258
dc.identifier.issn 1471-2407
dc.identifier.issn 1471-2407
dc.identifier.uri https://hdl.handle.net/10161/18028
dc.description.abstract Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase family plays crucial roles in carcinogenesis and progression of several cancers, including squamous cell carcinoma of the head and neck (SCCHN). A single nucleotide polymorphism (SNP, rs2274223) in PLCE1 has been identified as a novel susceptibility locus in genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) that share similar risk factors with SCCHN. Therefore, we investigated the association between potentially functional SNPs in PLCE1 and susceptibility to SCCHN.We genotyped three potentially functional SNPs (rs2274223A/G, rs3203713A/G and rs11599672T/G) of PLCE1 in 1,098 SCCHN patients and 1,090 controls matched by age and sex in a non-Hispanic white population.Although none of three SNPs was alone significantly associated with overall risk of SCCHN, their combined effects of risk alleles (rs2274223G, rs3203713G and rs11599672G) were found to be associated with risk of SCCHN in a locus-dose effect manner (Ptrend=0.046), particularly for non-oropharyngeal tumors (Ptrend=0.017); specifically, rs2274223 was associated with a significantly increased risk (AG vs. AA: adjusted OR=1.29, 95% CI=1.01-1.64; AG/GG vs. AA: adjusted OR=1.30, 95% CI=1.03-1.64), while rs11599672 was associated with a significantly decreased risk (GG vs. TT: adjusted OR=0.54, 95% CI=0.34-0.86; TG/GG vs. TT: adjusted OR=0.76, 95% CI=0.61-0.95).Our findings suggest that PLCE1 variants may have an effect on risk of SCCHN associated with tobacco and alcohol exposure, particularly for those tumors arising at non-oropharyngeal sites. These findings, although need to be validated by larger studies, are consistent with those in esophageal and gastric cancers.
dc.language eng
dc.publisher Springer Nature
dc.relation.ispartof BMC cancer
dc.relation.isversionof 10.1186/1471-2407-11-258
dc.subject Humans
dc.subject Carcinoma, Squamous Cell
dc.subject Esophageal Neoplasms
dc.subject Stomach Neoplasms
dc.subject Head and Neck Neoplasms
dc.subject Cocarcinogenesis
dc.subject Genetic Predisposition to Disease
dc.subject Neoplasm Proteins
dc.subject Risk
dc.subject Risk Factors
dc.subject Case-Control Studies
dc.subject Sequence Analysis, DNA
dc.subject Alcohol Drinking
dc.subject Smoking
dc.subject Organ Specificity
dc.subject Genotype
dc.subject Haplotypes
dc.subject Polymorphism, Single Nucleotide
dc.subject Alleles
dc.subject Aged
dc.subject Middle Aged
dc.subject United States
dc.subject Female
dc.subject Male
dc.subject Phosphoinositide Phospholipase C
dc.subject Genome-Wide Association Study
dc.title Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck.
dc.type Journal article
dc.date.updated 2019-02-01T15:29:00Z
pubs.begin-page 258
pubs.issue 1
pubs.organisational-group Staff
pubs.organisational-group Duke
pubs.organisational-group School of Medicine
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Population Health Sciences
pubs.organisational-group Basic Science Departments
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 11
duke.contributor.orcid Wei, Qingyi|0000-0002-3845-9445


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