CASP7 variants modify susceptibility to cervical cancer in Chinese women.
Abstract
Polymorphisms in Caspase-7 (CASP7) may modulate the programmed cell death and thus
contribute to cervical cancer risk. In this case-control study of 1,486 cervical cancer
cases and 1,301 controls, we investigated associations between four potentially functional
polymorphisms in CASP7 and cervical cancer risk and evaluated their locus-locus interaction
effects on the risk. The genotype-phenotype correlation was performed by a generalized
linear regression model. We found that the rs4353229 polymorphism was associated with
cervical cancer risk (under a recessive model: crude OR = 1.20, 95% CI = 1.02-1.40).
Compared with the TT genotype, the rs10787498GT genotype was associated with an increased
cervical cancer risk (adjusted OR = 1.19, 95% CI = 1.00-1.41). Combination analysis
showed that subjects with four putative risk genotypes had a 1.54-fold increased cancer
risk, compared with those who carried three or less putative risk genotypes. We also
observed significant locus-locus joint effects on the risk, which may be mediated
by the polymorphisms regulating CASP7 mRNA expression. Subsequent multifactor dimensionality
reduction and classification and regression tree analyses indicated that the CASP7
genotypes might have a locus-locus interaction effect that modulated cervical cancer
risk. Out data suggest that CASP7 polymorphisms may interact to modify cervical cancer
risk by a possible mechanism of regulating CASP7 mRNA expression.
Type
Journal articleSubject
HumansDisease Susceptibility
Genetic Predisposition to Disease
RNA, Messenger
Logistic Models
Odds Ratio
Case-Control Studies
Genotype
Polymorphism, Single Nucleotide
Alleles
China
Uterine Cervical Neoplasms
Female
Caspase 7
Genetic Loci
Genetic Association Studies
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https://hdl.handle.net/10161/18031Published Version (Please cite this version)
10.1038/srep09225Publication Info
Shi, Ting-Yan; He, Jing; Wang, Meng-Yun; Zhu, Mei-Ling; Yu, Ke-Da; Shao, Zhi-Ming;
... Wei, Qingyi (2015). CASP7 variants modify susceptibility to cervical cancer in Chinese women. Scientific reports, 5(1). pp. 9225. 10.1038/srep09225. Retrieved from https://hdl.handle.net/10161/18031.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Qingyi Wei
Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director
for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology
and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally
recognized epidemiologist focused on the molecular and genetic epidemiology of head
and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and
genetic determinants for the DNA repair deficient phenotype and

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