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Metrology Standards for Quantitative Imaging Biomarkers.

dc.contributor.author Barboriak, Daniel
dc.contributor.author Sullivan, Daniel
dc.contributor.author Obuchowski, Nancy A
dc.contributor.author Kessler, Larry G
dc.contributor.author Raunig, David L
dc.contributor.author Gatsonis, Constantine
dc.contributor.author Huang, Erich P
dc.contributor.author Kondratovich, Marina
dc.contributor.author McShane, Lisa M
dc.contributor.author Reeves, Anthony P
dc.contributor.author Guimaraes, Alexander R
dc.contributor.author Wahl, Richard L
dc.date.accessioned 2019-02-01T15:33:16Z
dc.date.available 2019-02-01T15:33:16Z
dc.date.issued 2015-12
dc.identifier.issn 0033-8419
dc.identifier.issn 1527-1315
dc.identifier.uri https://hdl.handle.net/10161/18036
dc.description.abstract Although investigators in the imaging community have been active in developing and evaluating quantitative imaging biomarkers (QIBs), the development and implementation of QIBs have been hampered by the inconsistent or incorrect use of terminology or methods for technical performance and statistical concepts. Technical performance is an assessment of how a test performs in reference objects or subjects under controlled conditions. In this article, some of the relevant statistical concepts are reviewed, methods that can be used for evaluating and comparing QIBs are described, and some of the technical performance issues related to imaging biomarkers are discussed. More consistent and correct use of terminology and study design principles will improve clinical research, advance regulatory science, and foster better care for patients who undergo imaging studies.
dc.language eng
dc.publisher Radiological Society of North America (RSNA)
dc.relation.ispartof Radiology
dc.relation.isversionof 10.1148/radiol.2015142202
dc.subject RSNA-QIBA Metrology Working Group
dc.subject Diagnostic Imaging
dc.subject Reproducibility of Results
dc.subject Phantoms, Imaging
dc.subject Reference Values
dc.subject Terminology as Topic
dc.subject Biomarkers
dc.subject Bias
dc.title Metrology Standards for Quantitative Imaging Biomarkers.
dc.type Journal article
dc.date.updated 2019-02-01T15:33:15Z
pubs.begin-page 813
pubs.end-page 825
pubs.issue 3
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Pediatrics
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Neurosurgery
pubs.organisational-group Radiology, Neuroradiology
pubs.organisational-group Radiology
pubs.organisational-group Duke Clinical Research Institute
pubs.publication-status Published
pubs.volume 277
duke.contributor.orcid Sullivan, Daniel|0000-0002-7556-5650


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