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Association between general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study.

dc.contributor.author Goode, Adam
dc.contributor.author Kraus, Virginia
dc.contributor.author Flowers, Portia PE
dc.contributor.author Cleveland, Rebecca J
dc.contributor.author Schwartz, Todd A
dc.contributor.author Nelson, Amanda E
dc.contributor.author Hillstrom, Howard J
dc.contributor.author Hannan, Marian T
dc.contributor.author Renner, Jordan B
dc.contributor.author Jordan, Joanne M
dc.contributor.author Golightly, Yvonne M
dc.date.accessioned 2019-02-02T15:30:59Z
dc.date.available 2019-02-02T15:30:59Z
dc.date.issued 2018-04-18
dc.identifier 10.1186/s13075-018-1570-7
dc.identifier.issn 1478-6354
dc.identifier.issn 1478-6362
dc.identifier.uri https://hdl.handle.net/10161/18049
dc.description.abstract BACKGROUND:Osteoarthritis (OA) prevalence differs by race. General joint hypermobility (GJH) may be associated with OA, but differences by race are not known. This community-based study examined the frequency of GJH and its relationship with knee, hip, and lumbar spine OA by race (African American vs. Caucasian). METHODS:Data were from the Johnston County OA project, collected 2003-2010. GJH was defined as Beighton score ≥4. OA symptoms were defined as the presence of pain, aching, or stiffness on most days separately at the knee, hip, and lower back. Radiographic OA (rOA) of the knee or hip was defined as Kellgren-Lawrence grade 2-4. Lumbar spine rOA was disc space narrowing grade ≥1 and osteophyte grade ≥2 in ≥ 1 at the same lumbar level. Lumbar spine facet rOA was present in ≥ 1 lumbar levels. Separate logistic regression models stratified by race were used to examine the association between hypermobility and rOA or OA symptoms at each joint site, adjusting for age, sex, previous joint injury, and body mass index (BMI). RESULTS:Of 1987 participants, 1/3 were African-American and 2/3 were women (mean age 65 years, mean BMI 31 kg/m2). Nearly 8% of Caucasians were hypermobile vs. 5% of African-Americans (p = 0.03). Hypermobility was associated with lower back symptoms in Caucasians (adjusted odds ratio (aOR) 1.54, 95% confidence interval (CI) 1.00, 2.39), but not in African-Americans (aOR 0.77, 95% CI 0.34, 1.72). Associations between hypermobility and other knee, hip, or lumbar spine/facet OA variables were not statistically significant. CONCLUSIONS:General joint hypermobility was more common in Caucasians than African-Americans. Although there were no associations between hypermobility and rOA, the association between hypermobility and lower back symptoms may differ by race.
dc.language eng
dc.publisher Springer Nature
dc.relation.ispartof Arthritis research & therapy
dc.relation.isversionof 10.1186/s13075-018-1570-7
dc.subject Cohort
dc.subject General joint hypermobility
dc.subject Osteoarthritis
dc.subject Pain
dc.subject Race
dc.title Association between general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study.
dc.type Journal article
dc.date.updated 2019-02-02T15:30:58Z
pubs.begin-page 76
pubs.issue 1
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Clinical Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Population Health Sciences
pubs.organisational-group Basic Science Departments
pubs.organisational-group Orthopaedics, Physical Therapy
pubs.organisational-group Orthopaedics
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke Molecular Physiology Institute
pubs.organisational-group Pathology
pubs.organisational-group Medicine, Rheumatology and Immunology
pubs.organisational-group Medicine
pubs.publication-status Published
pubs.volume 20


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