Serum N-propeptide of collagen IIA (PIIANP) as a marker of radiographic osteoarthritis burden.
Abstract
Cartilage homeostasis relies on a balance of catabolism and anabolism of cartilage
matrix. Our goal was to evaluate the burden of radiographic osteoarthritis and serum
levels of type IIA procollagen amino terminal propeptide (sPIIANP), a biomarker representing
type II collagen synthesis, in osteoarthritis.OA burden was quantified on the basis
of radiographic features as total joint faces with an osteophyte, joint space narrowing,
or in the spine, disc space narrowing. sPIIANP was measured in 1,235 participants
from the Genetics of Generalized Osteoarthritis study using a competitive enzyme-linked
immunosorbent assay. Separate multivariable linear regression models, adjusted for
age, sex, and body mass index and additionally for ipsilateral osteophytes or joint/disc
space narrowing, were used to assess the independent association of sPIIANP with osteophytes
and with joint/disc space narrowing burden in knees, hips, hands and spine, individually
and together.After full adjustment, sPIIANP was significantly associated with a lesser
burden of hip joint space narrowing and knee osteophytes. sPIIANP was associated with
a lesser burden of hand joint space narrowing but a greater burden of hand osteophytes;
these results were only evident upon adjustment for osteoarthritic features in all
other joints. There were no associations of sPIIANP and features of spine osteoarthritis.Higher
cartilage collagen synthesis, as reflected in systemic PIIANP concentrations, was
associated with lesser burden of osteoarthritic features in lower extremity joints
(knees and hips), even accounting for osteoarthritis burden in hands and spine, age,
sex and body mass index. These results suggest that pro-anabolic agents may be appropriate
for early treatment to prevent severe lower extremity large joint osteoarthritis.
Type
Journal articleSubject
HumansOsteoarthritis
Collagen Type II
Calcium-Binding Proteins
Enzyme-Linked Immunosorbent Assay
Female
Male
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https://hdl.handle.net/10161/18050Published Version (Please cite this version)
10.1371/journal.pone.0190251Publication Info
Daghestani, Hikmat N; Jordan, Joanne M; Renner, Jordan B; Doherty, Michael; Wilson,
A Gerry; & Kraus, Virginia B (2017). Serum N-propeptide of collagen IIA (PIIANP) as a marker of radiographic osteoarthritis
burden. PloS one, 12(12). pp. e0190251. 10.1371/journal.pone.0190251. Retrieved from https://hdl.handle.net/10161/18050.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Virginia Byers Kraus
Mary Bernheim Distinguished Professor of Medicine
Virginia Byers Kraus, MD, PhD, is the Mary Bernheim Distinguished Professor of Medicine,
Professor of Orthopaedic Surgery, Professor of Pathology and a faculty member of the
Duke Molecular Physiology Institute in the Duke University School of Medicine. She
is a practicing Rheumatologist with over 30 years’ experience in translational musculoskeletal
research focusing on osteoarthritis, the most common of all arthritides. She trained
at Brown University (ScB 1979), Duke University (MD 19

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