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Serum N-propeptide of collagen IIA (PIIANP) as a marker of radiographic osteoarthritis burden.

dc.contributor.author Kraus, Virginia
dc.contributor.author Daghestani, Hikmat N
dc.contributor.author Jordan, Joanne M
dc.contributor.author Renner, Jordan B
dc.contributor.author Doherty, Michael
dc.contributor.author Wilson, A Gerry
dc.date.accessioned 2019-02-02T15:31:19Z
dc.date.available 2019-02-02T15:31:19Z
dc.date.issued 2017-01
dc.identifier PONE-D-17-04833
dc.identifier.issn 1932-6203
dc.identifier.issn 1932-6203
dc.identifier.uri https://hdl.handle.net/10161/18050
dc.description.abstract Cartilage homeostasis relies on a balance of catabolism and anabolism of cartilage matrix. Our goal was to evaluate the burden of radiographic osteoarthritis and serum levels of type IIA procollagen amino terminal propeptide (sPIIANP), a biomarker representing type II collagen synthesis, in osteoarthritis.OA burden was quantified on the basis of radiographic features as total joint faces with an osteophyte, joint space narrowing, or in the spine, disc space narrowing. sPIIANP was measured in 1,235 participants from the Genetics of Generalized Osteoarthritis study using a competitive enzyme-linked immunosorbent assay. Separate multivariable linear regression models, adjusted for age, sex, and body mass index and additionally for ipsilateral osteophytes or joint/disc space narrowing, were used to assess the independent association of sPIIANP with osteophytes and with joint/disc space narrowing burden in knees, hips, hands and spine, individually and together.After full adjustment, sPIIANP was significantly associated with a lesser burden of hip joint space narrowing and knee osteophytes. sPIIANP was associated with a lesser burden of hand joint space narrowing but a greater burden of hand osteophytes; these results were only evident upon adjustment for osteoarthritic features in all other joints. There were no associations of sPIIANP and features of spine osteoarthritis.Higher cartilage collagen synthesis, as reflected in systemic PIIANP concentrations, was associated with lesser burden of osteoarthritic features in lower extremity joints (knees and hips), even accounting for osteoarthritis burden in hands and spine, age, sex and body mass index. These results suggest that pro-anabolic agents may be appropriate for early treatment to prevent severe lower extremity large joint osteoarthritis.
dc.language eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PloS one
dc.relation.isversionof 10.1371/journal.pone.0190251
dc.subject Humans
dc.subject Osteoarthritis
dc.subject Collagen Type II
dc.subject Calcium-Binding Proteins
dc.subject Enzyme-Linked Immunosorbent Assay
dc.subject Female
dc.subject Male
dc.title Serum N-propeptide of collagen IIA (PIIANP) as a marker of radiographic osteoarthritis burden.
dc.type Journal article
dc.date.updated 2019-02-02T15:31:17Z
pubs.begin-page e0190251
pubs.issue 12
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Molecular Physiology Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Orthopaedics
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Pathology
pubs.organisational-group Medicine, Rheumatology and Immunology
pubs.organisational-group Medicine
pubs.publication-status Published
pubs.volume 12


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