Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory
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<jats:p>Episodic memory retrieval relies on the recovery of neural representations of waking experience. This process is thought to involve a communication dynamic between the medial temporal lobe memory system and the neocortex. How this occurs is largely unknown, however, especially as it pertains to awake human memory retrieval. Using intracranial electroencephalographic recordings, we found that ripple oscillations were dynamically coupled between the human medial temporal lobe (MTL) and temporal association cortex. Coupled ripples were more pronounced during successful verbal memory retrieval and recover the cortical neural representations of remembered items. Together, these data provide direct evidence that coupled ripples between the MTL and association cortex may underlie successful memory retrieval in the human brain.</jats:p>
Published Version (Please cite this version)10.1126/science.aau8956
Publication InfoVaz, Alex; Brunel, Nicolas; Inati, Sara K; & Zaghloul, Kareem A (2019). Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory. Science, 363(6430). pp. 975-978. 10.1126/science.aau8956. Retrieved from https://hdl.handle.net/10161/18101.
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Professor of Neurobiology
We use theoretical models of brain systems to investigate how they process and learn information from their inputs. Our current work focuses on the mechanisms of learning and memory, from the synapse to the network level, in collaboration with various experimental groups. Using methods fromstatistical physics, we have shown recently that the synapticconnectivity of a network that maximizes storage capacity reproducestwo key experimentally observed features: low connection proba
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