Pulmonary Delivery of Therapeutic and Diagnostic Gases.
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The 21st Congress for the International Society for Aerosols in Medicine included, for the first time, a session on Pulmonary Delivery of Therapeutic and Diagnostic Gases. The rationale for such a session within ISAM is that the pulmonary delivery of gaseous drugs in many cases targets the same therapeutic areas as aerosol drug delivery, and is in many scientific and technical aspects similar to aerosol drug delivery. This article serves as a report on the recent ISAM congress session providing a synopsis of each of the presentations. The topics covered are the conception, testing, and development of the use of nitric oxide to treat pulmonary hypertension; the use of realistic adult nasal replicas to evaluate the performance of pulsed oxygen delivery devices; an overview of several diagnostic gas modalities; and the use of inhaled oxygen as a proton magnetic resonance imaging (MRI) contrast agent for imaging temporal changes in the distribution of specific ventilation during recovery from bronchoconstriction. Themes common to these diverse applications of inhaled gases in medicine are discussed, along with future perspectives on development of therapeutic and diagnostic gases.
Subjectin vitro upper airway model
magnetic resonance imaging (MRI)
Published Version (Please cite this version)10.1089/jamp.2017.1431
Publication InfoCharles, Hal; MacIntyre, Neil; Mammarappallil, Joseph; Moon, Richard; Zapol, Warren M; Martin, Andrew R; ... Katz, Ira (2018). Pulmonary Delivery of Therapeutic and Diagnostic Gases. Journal of aerosol medicine and pulmonary drug delivery, 31(2). pp. 78-87. 10.1089/jamp.2017.1431. Retrieved from https://hdl.handle.net/10161/18102.
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Associate Professor of Radiology
Dr. Charles is an Associate Professor of Radiology, a chemist and an expert in MR imaging and spectroscopy with over 40 years of experience in nuclear magnetic resonance. He serves as the Scientific Director of the Duke Center for Advanced Magnetic Resonance Development. He has had extensive experience in conducting longitudinal clinical trials with MRI and MRS used as imaging biomarkers. He is also director of the Duke Image Analysis Laboratory which is active in conducting c
Professor of Medicine
1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials
Assistant Professor of Radiology
Professor of Anesthesiology
Research interests include the study of cardiorespiratory function in humans exposed to environmental conditions ranging from 200 feet of seawater depth to high altitude, gas exchange during diving, the pathophysiology of high altitude pulmonary edema, the effect of anesthesia and postoperative analgesia on pulmonary function and monitoring of tissue oxygenation. Ongoing human studies include the use of fractals to study breathing patterns during environmental and perioperative stress, mechanism
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