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A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling.

dc.contributor.author Price, Thomas
dc.contributor.author Dai, Qunsheng
dc.contributor.author Likes, Creighton E
dc.contributor.author Luz, Anthony L
dc.contributor.author Mao, Lan
dc.contributor.author Yeh, Jason S
dc.contributor.author Wei, Zhengzheng
dc.contributor.author Kuchibhatla, Maragatha
dc.contributor.author Ilkayeva, Olga R
dc.contributor.author Koves, Timothy R
dc.date.accessioned 2019-03-01T14:56:24Z
dc.date.available 2019-03-01T14:56:24Z
dc.date.issued 2019-02
dc.identifier js_201800219
dc.identifier.issn 2472-1972
dc.identifier.issn 2472-1972
dc.identifier.uri https://hdl.handle.net/10161/18107
dc.description.abstract Progesterone is primarily a pregnancy-related hormone, produced in substantial quantities after ovulation and during gestation. Traditionally known to function via nuclear receptors for transcriptional regulation, there is also evidence of nonnuclear action. A previously identified mitochondrial progesterone receptor (PR-M) increases cellular respiration in cell models. In these studies, we demonstrated that expression of PR-M in rat H9c2 cardiomyocytes resulted in a ligand-dependent increase in oxidative cellular respiration and beta-oxidation. Cardiac expression in a TET-On transgenic mouse resulted in gene expression of myofibril proteins for remodeling and proteins involved in oxidative phosphorylation and fatty acid metabolism. In a model of increased afterload from constant transverse aortic constriction, mice expressing PR-M showed a ligand-dependent preservation of cardiac function. From these observations, we propose that PR-M is responsible for progesterone-induced increases in cellular energy production and cardiac remodeling to meet the physiological demands of pregnancy.
dc.language eng
dc.publisher The Endocrine Society
dc.relation.ispartof Journal of the Endocrine Society
dc.relation.isversionof 10.1210/js.2018-00219
dc.subject beta-oxidation
dc.subject mitochondria
dc.subject pregnancy
dc.subject progesterone
dc.subject respiratory chain
dc.title A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling.
dc.type Journal article
dc.date.updated 2019-03-01T14:56:22Z
pubs.begin-page 446
pubs.end-page 467
pubs.issue 2
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Obstetrics and Gynecology, Reproductive Endocrinology & Fertility
pubs.organisational-group Obstetrics and Gynecology
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 3


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