Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
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Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.
Published Version (Please cite this version)10.1038/s41418-017-0012-4
Publication InfoChan, Francis; DUCKETT, COLIN; Galluzzi, Lorenzo; Vitale, Ilio; Aaronson, Stuart A; Abrams, John M; ... Kroemer, Guido (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell death and differentiation, 25(3). pp. 486-541. 10.1038/s41418-017-0012-4. Retrieved from https://hdl.handle.net/10161/18128.
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Professor of Immunology
Our lab is interested in how cell death impacts innate inflammation and immune responses. We have a long-standing interest in the biology and signaling mechanism of tumor necrosis factor (TNF), a key cytokine that regulates many inflammatory diseases (e.g. rheumatoid arthritis, inflammatory bowel diseases etc), pathogen infections, and cancer. Several key discoveries made by the PI during his graduate school and postdoctoral training include identification of one of the first cell cy
Research Professor of Pharmacology and Cancer Biology
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