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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

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Date
2018-03
Authors
Galluzzi, Lorenzo
Vitale, Ilio
Aaronson, Stuart A
Abrams, John M
Adam, Dieter
Agostinis, Patrizia
Alnemri, Emad S
Altucci, Lucia
Amelio, Ivano
Andrews, David W
Annicchiarico-Petruzzelli, Margherita
Antonov, Alexey V
Arama, Eli
Baehrecke, Eric H
Barlev, Nickolai A
Bazan, Nicolas G
Bernassola, Francesca
Bertrand, Mathieu JM
Bianchi, Katiuscia
Blagosklonny, Mikhail V
Blomgren, Klas
Borner, Christoph
Boya, Patricia
Brenner, Catherine
Campanella, Michelangelo
Candi, Eleonora
Carmona-Gutierrez, Didac
Cecconi, Francesco
Chan, Francis K-M
Chandel, Navdeep S
Cheng, Emily H
Chipuk, Jerry E
Cidlowski, John A
Ciechanover, Aaron
Cohen, Gerald M
Conrad, Marcus
Cubillos-Ruiz, Juan R
Czabotar, Peter E
D'Angiolella, Vincenzo
Dawson, Ted M
Dawson, Valina L
De Laurenzi, Vincenzo
De Maria, Ruggero
Debatin, Klaus-Michael
DeBerardinis, Ralph J
Deshmukh, Mohanish
Di Daniele, Nicola
Di Virgilio, Francesco
Dixit, Vishva M
Dixon, Scott J
Duckett, Colin S
Dynlacht, Brian D
El-Deiry, Wafik S
Elrod, John W
Fimia, Gian Maria
Fulda, Simone
García-Sáez, Ana J
Garg, Abhishek D
Garrido, Carmen
Gavathiotis, Evripidis
Golstein, Pierre
Gottlieb, Eyal
Green, Douglas R
Greene, Lloyd A
Gronemeyer, Hinrich
Gross, Atan
Hajnoczky, Gyorgy
Hardwick, J Marie
Harris, Isaac S
Hengartner, Michael O
Hetz, Claudio
Ichijo, Hidenori
Jäättelä, Marja
Joseph, Bertrand
Jost, Philipp J
Juin, Philippe P
Kaiser, William J
Karin, Michael
Kaufmann, Thomas
Kepp, Oliver
Kimchi, Adi
Kitsis, Richard N
Klionsky, Daniel J
Knight, Richard A
Kumar, Sharad
Lee, Sam W
Lemasters, John J
Levine, Beth
Linkermann, Andreas
Lipton, Stuart A
Lockshin, Richard A
López-Otín, Carlos
Lowe, Scott W
Luedde, Tom
Lugli, Enrico
MacFarlane, Marion
Madeo, Frank
Malewicz, Michal
Malorni, Walter
Manic, Gwenola
Marine, Jean-Christophe
Martin, Seamus J
Martinou, Jean-Claude
Medema, Jan Paul
Mehlen, Patrick
Meier, Pascal
Melino, Sonia
Miao, Edward A
Molkentin, Jeffery D
Moll, Ute M
Muñoz-Pinedo, Cristina
Nagata, Shigekazu
Nuñez, Gabriel
Oberst, Andrew
Oren, Moshe
Overholtzer, Michael
Pagano, Michele
Panaretakis, Theocharis
Pasparakis, Manolis
Penninger, Josef M
Pereira, David M
Pervaiz, Shazib
Peter, Marcus E
Piacentini, Mauro
Pinton, Paolo
Prehn, Jochen HM
Puthalakath, Hamsa
Rabinovich, Gabriel A
Rehm, Markus
Rizzuto, Rosario
Rodrigues, Cecilia MP
Rubinsztein, David C
Rudel, Thomas
Ryan, Kevin M
Sayan, Emre
Scorrano, Luca
Shao, Feng
Shi, Yufang
Silke, John
Simon, Hans-Uwe
Sistigu, Antonella
Stockwell, Brent R
Strasser, Andreas
Szabadkai, Gyorgy
Tait, Stephen WG
Tang, Daolin
Tavernarakis, Nektarios
Thorburn, Andrew
Tsujimoto, Yoshihide
Turk, Boris
Vanden Berghe, Tom
Vandenabeele, Peter
Vander Heiden, Matthew G
Villunger, Andreas
Virgin, Herbert W
Vousden, Karen H
Vucic, Domagoj
Wagner, Erwin F
Walczak, Henning
Wallach, David
Wang, Ying
Wells, James A
Wood, Will
Yuan, Junying
Zakeri, Zahra
Zhivotovsky, Boris
Zitvogel, Laurence
Melino, Gerry
Kroemer, Guido
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(169 total)
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Abstract
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.
Type
Journal article
Permalink
https://hdl.handle.net/10161/18128
Published Version (Please cite this version)
10.1038/s41418-017-0012-4
Publication Info
Galluzzi, Lorenzo; Vitale, Ilio; Aaronson, Stuart A; Abrams, John M; Adam, Dieter; Agostinis, Patrizia; ... Kroemer, Guido (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell death and differentiation, 25(3). pp. 486-541. 10.1038/s41418-017-0012-4. Retrieved from https://hdl.handle.net/10161/18128.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Chan

Francis Ka-Ming Chan

Adjunct Professor in the Department of Immunology
Our lab is interested in how cell death impacts innate inflammation and immune responses.  We have a long-standing interest in the biology and signaling mechanism of tumor necrosis factor (TNF), a key cytokine that regulates many inflammatory diseases (e.g. rheumatoid arthritis, inflammatory bowel diseases etc), pathogen infections, and cancer.  Several key discoveries made by the PI during his graduate school and postdoctoral training include identification of one of the first cell cy
Duckett

Colin S Duckett

Professor of Pathology
Miao

Edward A. Miao

Chancellor's Distinguished Professor of Immunology
Programmed cell death directly counteracts intracellular infection by eliminating compromised host cells.   Pyroptotic cell death triggered by caspase-1/11 was described in 1992, but remained a possible cell culture artifact for many years. We were the first to use in vivo animal models to demonstrate that pyroptosis clears intracellular bacteria. Pyroptosis traps the bacteria within the cellular remains while simultaneously attracting ne
Alphabetical list of authors with Scholars@Duke profiles.
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