Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Abstract
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological,
biochemical, and functional perspectives. Since the field continues to expand and
novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose
an updated classification of cell death subroutines focusing on mechanistic and essential
(as opposed to correlative and dispensable) aspects of the process. As we provide
molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic
apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis,
ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent
cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence,
and mitotic catastrophe, we discuss the utility of neologisms that refer to highly
specialized instances of these processes. The mission of the NCCD is to provide a
widely accepted nomenclature on cell death in support of the continued development
of the field.
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https://hdl.handle.net/10161/18128Published Version (Please cite this version)
10.1038/s41418-017-0012-4Publication Info
Galluzzi, Lorenzo; Vitale, Ilio; Aaronson, Stuart A; Abrams, John M; Adam, Dieter;
Agostinis, Patrizia; ... Kroemer, Guido (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee
on Cell Death 2018. Cell death and differentiation, 25(3). pp. 486-541. 10.1038/s41418-017-0012-4. Retrieved from https://hdl.handle.net/10161/18128.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Francis Ka-Ming Chan
Adjunct Professor in the Department of Immunology
Our lab is interested in how cell death impacts innate inflammation and immune responses.
We have a long-standing interest in the biology and signaling mechanism of tumor necrosis
factor (TNF), a key cytokine that regulates many inflammatory diseases (e.g. rheumatoid
arthritis, inflammatory bowel diseases etc), pathogen infections, and cancer. Several
key discoveries made by the PI during his graduate school and postdoctoral training
include identification of one of the first cell cy
Colin S Duckett
Professor of Pathology
Edward A. Miao
Chancellor's Distinguished Professor of Immunology
Programmed cell death directly counteracts intracellular infection by eliminating
compromised host cells.
Pyroptotic cell death triggered by caspase-1/11 was described in 1992, but remained
a possible cell culture artifact for many years. We were the first to use in vivo
animal models to demonstrate that pyroptosis clears intracellular bacteria. Pyroptosis
traps the bacteria within the cellular remains while simultaneously attracting ne
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