Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans.
Abstract
Humans are frequently exposed to acrylamide, a probable human carcinogen found in
commonplace sources such as most heated starchy foods or tobacco smoke. Prior evidence
has shown that acrylamide causes cancer in rodents, yet epidemiological studies conducted
to date are limited and, thus far, have yielded inconclusive data on association of
human cancers with acrylamide exposure. In this study, we experimentally identify
a novel and unique mutational signature imprinted by acrylamide through the effects
of its reactive metabolite glycidamide. We next show that the glycidamide mutational
signature is found in a full one-third of approximately 1600 tumor genomes corresponding
to 19 human tumor types from 14 organs. The highest enrichment of the glycidamide
signature was observed in the cancers of the lung (88% of the interrogated tumors),
liver (73%), kidney (>70%), bile duct (57%), cervix (50%), and, to a lesser extent,
additional cancer types. Overall, our study reveals an unexpectedly extensive contribution
of acrylamide-associated mutagenesis to human cancers.
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https://hdl.handle.net/10161/18203Published Version (Please cite this version)
10.1101/gr.242453.118Publication Info
Zhivagui, Maria; Ng, Alvin WT; Ardin, Maude; Churchwell, Mona I; Pandey, Manuraj;
Renard, Claire; ... Zavadil, Jiri (2019). Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide
exposure to carcinogenesis in humans. Genome research. 10.1101/gr.242453.118. Retrieved from https://hdl.handle.net/10161/18203.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Steven George Rozen
Associate Professor in Psychiatry and Behavioral Sciences

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