Show simple item record

Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans.

dc.contributor.author Rozen, Steven
dc.contributor.author Zhivagui, Maria
dc.contributor.author Ng, Alvin WT
dc.contributor.author Ardin, Maude
dc.contributor.author Churchwell, Mona I
dc.contributor.author Pandey, Manuraj
dc.contributor.author Renard, Claire
dc.contributor.author Villar, Stephanie
dc.contributor.author Cahais, Vincent
dc.contributor.author Robitaille, Alexis
dc.contributor.author Bouaoun, Liacine
dc.contributor.author Heguy, Adriana
dc.contributor.author Guyton, Kathryn Z
dc.contributor.author Stampfer, Martha R
dc.contributor.author McKay, James
dc.contributor.author Hollstein, Monica
dc.contributor.author Olivier, Magali
dc.contributor.author Beland, Frederick A
dc.contributor.author Korenjak, Michael
dc.contributor.author Zavadil, Jiri
dc.date.accessioned 2019-04-02T12:30:19Z
dc.date.available 2019-04-02T12:30:19Z
dc.date.issued 2019-03-07
dc.identifier gr.242453.118
dc.identifier.issn 1088-9051
dc.identifier.issn 1549-5469
dc.identifier.uri https://hdl.handle.net/10161/18203
dc.description.abstract Humans are frequently exposed to acrylamide, a probable human carcinogen found in commonplace sources such as most heated starchy foods or tobacco smoke. Prior evidence has shown that acrylamide causes cancer in rodents, yet epidemiological studies conducted to date are limited and, thus far, have yielded inconclusive data on association of human cancers with acrylamide exposure. In this study, we experimentally identify a novel and unique mutational signature imprinted by acrylamide through the effects of its reactive metabolite glycidamide. We next show that the glycidamide mutational signature is found in a full one-third of approximately 1600 tumor genomes corresponding to 19 human tumor types from 14 organs. The highest enrichment of the glycidamide signature was observed in the cancers of the lung (88% of the interrogated tumors), liver (73%), kidney (>70%), bile duct (57%), cervix (50%), and, to a lesser extent, additional cancer types. Overall, our study reveals an unexpectedly extensive contribution of acrylamide-associated mutagenesis to human cancers.
dc.language eng
dc.publisher Cold Spring Harbor Laboratory
dc.relation.ispartof Genome research
dc.relation.isversionof 10.1101/gr.242453.118
dc.title Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans.
dc.type Journal article
dc.date.updated 2019-04-02T12:30:17Z
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Psychiatry & Behavioral Sciences, Translational Neuroscience
pubs.organisational-group Psychiatry & Behavioral Sciences
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
duke.contributor.orcid Rozen, Steven|0000-0002-4288-0056


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record