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Novel antiplatelet agent ticagrelor in the management of acute coronary syndrome.

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Date
2011-06
Authors
Ramaraj, Radhakrishnan
Movahed, Mohammad Reza
Hashemzadeh, Mehrnoosh
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Abstract
Current clinical guidelines recommend dual antiplatelet agents namely aspirin and clopidogrel for the treatment of patients suffering from acute coronary syndrome (ACS). But the efficacy of clopidogrel is variable as it is a pro-drug, which has to be metabolized to become an active drug thus exhibiting variable platelet inhibition, increases risk of bleeding, stent thrombosis, and ischemia. To overcome this limitation, prasugrel was developed with increased antiplatelet activity thereby reducing the risk of myocardial ischemia and stent thrombosis. This action of prasugrel was associated with an increased risk of major bleeding. Finally, a novel reversible and direct-acting oral adenosine diphosphate (ADP) receptor antagonist, ticagrelor was developed that showed consistent and increased P2Y12 inhibition with similar incidence of bleeding but greater reduction in cardiac events compared to clopidogrel. The focus of this article is to review ticagrelor as a new class of P2Y12 inhibitor.
Type
Journal article
Subject
Humans
Adenosine
Acute Coronary Syndrome
Purinergic P2Y Receptor Antagonists
Permalink
https://hdl.handle.net/10161/18599
Published Version (Please cite this version)
10.1111/j.1540-8183.2010.00613.x
Publication Info
Ramaraj, Radhakrishnan; Movahed, Mohammad Reza; & Hashemzadeh, Mehrnoosh (2011). Novel antiplatelet agent ticagrelor in the management of acute coronary syndrome. Journal of interventional cardiology, 24(3). pp. 199-207. 10.1111/j.1540-8183.2010.00613.x. Retrieved from https://hdl.handle.net/10161/18599.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Radhakrishnan Ramaraj

Clinical Associate in the Department of Medicine
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
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