Feasibility of using an epigenetic marker of risk for lung cancer, methylation of p16, to promote smoking cessation among US veterans.
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Providing smokers feedback using epigenetic markers of lung cancer risk has yet to be tested as a strategy to motivate smoking cessation. Epigenetic modification of Rb-p16 (p16) due to tobacco exposure is associated with increased risk of developing lung cancer. This study examined the acceptance of testing for methylated p16 and the understanding of test results in smokers at risk for development of lung cancer.Thirty-five current smokers with airways obstruction viewed an educational presentation regarding p16 function followed by testing for the presence of methylated p16 in sputum. Participants were offered smoking cessation assistance and asked to complete surveys at the time of enrolment regarding their understanding of the educational material, perception of risk associated with smoking and desire to quit. Participants were notified of their test result and follow-up surveys were administered 2 and 10 weeks after notification of their test result.Twenty per cent of participants had methylated p16. Participants showed high degree of understanding of educational materials regarding the function and risk associated with p16 methylation. Sixty-seven per cent and 57% of participants with low-risk and high-risk test results, respectively, reported that the information was more likely to motivate them to quit smoking. Smoking cessation rates were similar between methylated and non-methylated participants.Testing for an epigenetic marker of lung cancer risk is accepted and understood by active smokers. A low-risk test result does not decrease motivation to stop smoking.NCT01038492.
Published Version (Please cite this version)10.1136/bmjresp-2014-000032
Publication InfoLipkus, Isaac; Wahidi, Momen; Kelley, Michael; Shofer, Scott; Beyea, Matthew; Li, Sufeng; & Bastian, Lori A (2014). Feasibility of using an epigenetic marker of risk for lung cancer, methylation of p16, to promote smoking cessation among US veterans. BMJ open respiratory research, 1(1). pp. e000032. 10.1136/bmjresp-2014-000032. Retrieved from https://hdl.handle.net/10161/18620.
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Professor of Medicine
1. A major theme throughout my career has been the biology of and improving outcomes for patients with lung cancer. Early publications examined the relationship between specific genetic alterations in lung cancer and clinically relevant applications including differential drug sensitivity, differentiation of metastases from second primary cancers, and application of patient-specific mutations as epitopes for immunotherapy. Correlation of alteration of p16 w
Professor in the School of Nursing, with tenure
Research Interests Dr. Lipkus is interested in how: 1) dispositional (e.g., hostility) and attitudinal variables (e.g., belief in a world) affect coping with negative life events (e.g., cancer, conflict in interpersonal relationships), and 2) the impact of risk perceptions (e.g., optimistic and pessimistic biases) on modifying precautionary behaviors (e.g., early prevention and detection of cancer,etc.).
Associate Professor of Medicine
Associate Professor of Medicine
Emphysema, Lung Nodules, Lung Cancer, Bronchoscopy, Pleural Diseases
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