Pulmonary blastomycosis presenting as primary lung cancer.
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BACKGROUND:Blastomycosis is an endemic mycosis in North America that is caused by the dimorphic fungus Blastomyces dermatitidis. The illness is a systemic disease with a wide variety of pulmonary and extra-pulmonary manifestations. The initial presentation of blastomycosis may easily be mistaken for other infectious or non-infectious etiologies. CASE PRESENTATION:We present the case of a 52-year-old African-American male and former smoker that presented to his primary care provider with a 2-week history of non-productive cough, night sweats and weight loss. Initially diagnosed with primary lung malignancy, the patient was subsequently found to have pulmonary blastomycosis mimicking lung cancer. The patient underwent a successful course of treatment with posaconazole. CONCLUSIONS:Chronic blastomycosis can present with clinical and radiographic features indistinguishable from thoracic malignancies. There is no clinical syndrome specific for blastomycosis, thus a high degree of suspicion is required for early diagnosis. In this case report, we review recent evidence in radiographic features, diagnostic considerations and treatment of the disease.
Tomography, X-Ray Computed
Positron Emission Tomography Computed Tomography
Published Version (Please cite this version)10.1186/s12879-018-3244-0
Publication InfoHussaini, Syed Mohammed Qasim; Madut, Deng; Tong, Betty C; Pavlisko, Elizabeth N; Schell, Wiley A; Perfect, John R; & Thielman, Nathan M (2018). Pulmonary blastomycosis presenting as primary lung cancer. BMC infectious diseases, 18(1). pp. 336. 10.1186/s12879-018-3244-0. Retrieved from https://hdl.handle.net/10161/18966.
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Assistant Professor of Medicine
I am an infectious diseases doctors who specializes in the care of patients with general infectious diseases, including persons living with HIV. My research is focused on understanding the health-seeking behaviors and health outcomes for persons living with HIV in low-resource settings. In addition, I am interesting in understanding the etiologies of febrile illness among populations living in low-resource settings.
Associate Professor of Pathology
Dr. Pavlisko holds an undergraduate degree in Biochemistry from Clemson University and received her Doctor of Medicine from the Medical University of South Carolina. She completed her residency and is board certified in both Anatomic and Clinical Pathology. She trained as a pulmonary/thoracic pathology fellow at Duke University Medical Center under the mentorship of Drs. Victor Roggli and Thomas Sporn, two of the world’s leading Pulmonary Pathologist with expertise in pneumoconiosi
James B. Duke Distinguished Professor of Medicine
Research in my laboratory focuses around several aspects of medical mycology. We are investigating antifungal agents (new and old) in animal models of candida and cryptococcal infections. We have examined clinical correlation of in vitro antifungal susceptibility testing and with in vivo outcome. Our basic science project examines the molecular pathogenesis of cryptococcal infections. We have developed a molecular foundation for C. neoformans, including transformation systems, gene disr
Associate Professor in Medicine
Professor of Medicine
Broadly, my research focuses on a range of clinical and social issues that affect persons living with or at risk for HIV infection in resource-poor settings. In Tanzania, our group is applying novel methods to optimize HIV testing uptake among high-risk groups. We recently demonstrated that the Discrete Choice Experiment (DCE), a form of stated preference survey research, is a robust tool for identifying (a) which characteristics of HIV testing options are most preferred by different populati
Associate Professor of Surgery
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