Pulmonary blastomycosis presenting as primary lung cancer.
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BACKGROUND:Blastomycosis is an endemic mycosis in North America that is caused by the dimorphic fungus Blastomyces dermatitidis. The illness is a systemic disease with a wide variety of pulmonary and extra-pulmonary manifestations. The initial presentation of blastomycosis may easily be mistaken for other infectious or non-infectious etiologies. CASE PRESENTATION:We present the case of a 52-year-old African-American male and former smoker that presented to his primary care provider with a 2-week history of non-productive cough, night sweats and weight loss. Initially diagnosed with primary lung malignancy, the patient was subsequently found to have pulmonary blastomycosis mimicking lung cancer. The patient underwent a successful course of treatment with posaconazole. CONCLUSIONS:Chronic blastomycosis can present with clinical and radiographic features indistinguishable from thoracic malignancies. There is no clinical syndrome specific for blastomycosis, thus a high degree of suspicion is required for early diagnosis. In this case report, we review recent evidence in radiographic features, diagnostic considerations and treatment of the disease.
Tomography, X-Ray Computed
Positron Emission Tomography Computed Tomography
Published Version (Please cite this version)10.1186/s12879-018-3244-0
Publication InfoHussaini, Syed; Thielman, Nathan; Pavlisko, Elizabeth; Tong, Betty; Schell, Wiley; Perfect, John; & Madut, Dr (2018). Pulmonary blastomycosis presenting as primary lung cancer. BMC infectious diseases, 18(1). pp. 336. 10.1186/s12879-018-3244-0. Retrieved from https://hdl.handle.net/10161/18966.
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Clinical Associate in the Department of Medicine, Infectious
I am an infectious diseases doctors who specializes in the care of patients with general infectious diseases, including persons living with HIV. My research is focused on understanding the health-seeking behaviors and health outcomes for persons living with HIV in low-resource settings. In addition, I am interesting in understanding the etiologies of febrile illness among populations living in low-resource settings.
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
Assistant Professor of Pathology
Dr. Pavlisko joined the faculty in 2011 as an Assistant Professor of Pathology at Duke University Medical Center where her work is focused in thoracic, cardiovascular and transplant pathology as well as postmortem examination. She is the co-author of the chapter Mesothelioma in the 3rd edition of Pathology of Asbestos-Associated Diseases, the chapter Lung Cancer in the new text titled Occupational Cancer (both of which were published in 2014), and the chapter Diseases of Se
James B. Duke Professor of Medicine
Research in my laboratory focuses around several aspects of medical mycology. We are investigating antifungal agents (new and old) in animal models of candida and cryptococcal infections. We have examined clinical correlation of in vitro antifungal susceptibility testing and with in vivo outcome. Our basic science project examines the molecular pathogenesis of cryptococcal infections. We have developed a molecular foundation for C. neoformans, including transformation systems, gene disr
Associate Professor in Medicine
Professor of Medicine
Broadly, my research focuses on a range of clinical and social issues that affect persons living with or at risk for HIV infection in resource-poor settings. In Tanzania, our group is applying novel methods to optimize HIV testing uptake among high-risk groups. We recently demonstrated that the Discrete Choice Experiment (DCE), a form of stated preference survey research, is a robust tool for identifying (a) which characteristics of HIV testing options are most preferred by different populati
Associate Professor of Surgery
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