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Pulmonary blastomycosis presenting as primary lung cancer.

dc.contributor.author Hussaini, Syed
dc.contributor.author Thielman, Nathan
dc.contributor.author Pavlisko, Elizabeth
dc.contributor.author Tong, Betty
dc.contributor.author Schell, Wiley
dc.contributor.author Perfect, John
dc.contributor.author Madut, Dr
dc.date.accessioned 2019-06-21T17:45:28Z
dc.date.available 2019-06-21T17:45:28Z
dc.date.issued 2018-07-18
dc.identifier 10.1186/s12879-018-3244-0
dc.identifier.issn 1471-2334
dc.identifier.issn 1471-2334
dc.identifier.uri https://hdl.handle.net/10161/18966
dc.description.abstract BACKGROUND:Blastomycosis is an endemic mycosis in North America that is caused by the dimorphic fungus Blastomyces dermatitidis. The illness is a systemic disease with a wide variety of pulmonary and extra-pulmonary manifestations. The initial presentation of blastomycosis may easily be mistaken for other infectious or non-infectious etiologies. CASE PRESENTATION:We present the case of a 52-year-old African-American male and former smoker that presented to his primary care provider with a 2-week history of non-productive cough, night sweats and weight loss. Initially diagnosed with primary lung malignancy, the patient was subsequently found to have pulmonary blastomycosis mimicking lung cancer. The patient underwent a successful course of treatment with posaconazole. CONCLUSIONS:Chronic blastomycosis can present with clinical and radiographic features indistinguishable from thoracic malignancies. There is no clinical syndrome specific for blastomycosis, thus a high degree of suspicion is required for early diagnosis. In this case report, we review recent evidence in radiographic features, diagnostic considerations and treatment of the disease.
dc.language eng
dc.publisher Springer Nature
dc.relation.ispartof BMC infectious diseases
dc.relation.isversionof 10.1186/s12879-018-3244-0
dc.subject Lung
dc.subject Humans
dc.subject Blastomyces
dc.subject Blastomycosis
dc.subject Lung Neoplasms
dc.subject Triazoles
dc.subject DNA, Fungal
dc.subject Antifungal Agents
dc.subject Diagnosis, Differential
dc.subject Tomography, X-Ray Computed
dc.subject Middle Aged
dc.subject Male
dc.subject Positron Emission Tomography Computed Tomography
dc.title Pulmonary blastomycosis presenting as primary lung cancer.
dc.type Journal article
dc.date.updated 2019-06-21T17:45:26Z
pubs.begin-page 336
pubs.issue 1
pubs.organisational-group Staff
pubs.organisational-group Duke
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.organisational-group School of Medicine
pubs.organisational-group Duke Global Health Institute
pubs.organisational-group University Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Pathology
pubs.organisational-group Medicine, Infectious Diseases
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Surgery, Cardiovascular and Thoracic Surgery
pubs.organisational-group Surgery
pubs.organisational-group Molecular Genetics and Microbiology
pubs.organisational-group Basic Science Departments
pubs.publication-status Published
pubs.volume 18
duke.contributor.orcid Hussaini, Syed|0000-0002-8006-5343
duke.contributor.orcid Pavlisko, Elizabeth|0000-0001-9598-3369
duke.contributor.orcid Tong, Betty|0000-0002-3345-3124
duke.contributor.orcid Perfect, John|0000-0002-6606-9460


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